Tabbara K F, Sakuragi S, Hall J, Frey B
Am J Ophthalmol. 1982 Sep;94(3):388-94. doi: 10.1016/0002-9394(82)90366-x.
In order to evaluate the effect of perilimbal conjunctival resection on the corneal immune response, we immunized rabbits with either intravenous or topical administration of bovine gamma globulin. After unilateral perilimbal conjunctival resection, the corneas were challenged with intracorneal injections of bovine gamma globulin. Perilimbal conjunctival resection prevented the development of peripheral corneal infiltrates in the rabbits immunized intravenously (P less than .0016) but not in those immunized topically. All the animals developed antibody titers to bovine gamma globulin. Similarly, perilimbal conjunctival resection did not prevent corneal graft rejection in rabbits sensitized to their donors by previous skin grafting.
为了评估角膜缘结膜切除术对角膜免疫反应的影响，我们通过静脉注射或局部给药牛γ球蛋白对兔子进行免疫。在单侧角膜缘结膜切除术后，通过角膜内注射牛γ球蛋白对角膜进行刺激。角膜缘结膜切除术可防止静脉注射免疫的兔子出现周边角膜浸润（P小于0.0016），但不能防止局部免疫的兔子出现周边角膜浸润。所有动物均产生了针对牛γ球蛋白的抗体滴度。同样，角膜缘结膜切除术也不能防止先前通过皮肤移植对供体致敏的兔子发生角膜移植排斥反应。
