Smolin G, Okumoto M, Hall J M, Friedlaender M
Ann Ophthalmol. 1979 Feb;11(2):227-232.
To study the effect of locally administered indoxole (with polysorbate 80) on the inflammatory and immunologic responses, we made unilateral intracorneal injections of rabbit eyes with bovine gamma globulin (BGG). The indoxole was injected subconjunctivally one day before, and 1, 2, 3, and 5 days after the BGG injection. The homolateral lymph nodes, uveal tracts, and corneas of rabbits killed on postinjection days 6 and 12 were tested for antibody-forming cells (AFC) by a modification of the Jerne plaque technique. On day 6 the indoxole-treated eyes were more inflamed and had a greater number of AFC in the tested tissues than the control eyes, but in neither of these respects was there any essential difference between the treated and control eyes on day 12. The possible mechanisms by which indoxole achieved its effect were explored.
为研究局部应用吲哚洛尔（含聚山梨酯80）对炎症和免疫反应的影响，我们用牛γ球蛋白（BGG）对兔眼进行单侧角膜内注射。在BGG注射前一天以及注射后1、2、3和5天，结膜下注射吲哚洛尔。对在注射后第6天和第12天处死的兔子的同侧淋巴结、葡萄膜和角膜，通过改良的耶尔恩斑技术检测抗体形成细胞（AFC）。在第6天，吲哚洛尔治疗组的眼睛比对照组更炎症，且在检测组织中的AFC数量更多，但在第12天，治疗组和对照组的眼睛在这两方面均无本质差异。探讨了吲哚洛尔发挥其作用的可能机制。
