Blancou J, Andral L, Mannen K
Comp Immunol Microbiol Infect Dis. 1982;5(1-3):95-9. doi: 10.1016/0147-9571(82)90020-0.
One hundred and sixteen rabies field isolates from France were studied with monoclonal antibodies for analysis of their nucleocapside antigenic characteristics (by direct or indirect immunofluorescence) or glycoprotein determinants (by neutralization in mice). These studies verified that nucleocapside antigens had only two variants, apparently uncorrelated to animal species or geographic areas. Glycoprotein antigens had also variants which could explain partial defection in cross protection observed in mice having received rabies vaccine prepared from heterologous strains.
对来自法国的116株狂犬病野外分离株，运用单克隆抗体进行研究，以分析其核衣壳抗原特性（通过直接或间接免疫荧光法）或糖蛋白决定簇（通过小鼠体内中和试验）。这些研究证实，核衣壳抗原仅有两种变体，显然与动物种类或地理区域无关。糖蛋白抗原也存在变体，这可以解释在接种了由异源毒株制备的狂犬病疫苗的小鼠中观察到的交叉保护作用部分失效的现象。
