Schneider L G
Comp Immunol Microbiol Infect Dis. 1982;5(1-3):101-7. doi: 10.1016/0147-9571(82)90021-2.
Monoclonal antibodies directed either against the nucleocapsid or the glycoprotein of rabies virus were reacted by indirect immunofluorescence and mouse neutralization tests with vaccine strains and rabies field isolates of various origin. Major antigenic determinants allow the grouping of viruses and minor ones the differentiation of virus strains. A protection study showed the existence in nature of certain antigenic variants against which conventional vaccines do not fully protect. The isolation of two such variants from 'imported' bats in the Federal Republic of Germany is reported here for the first time.
用间接免疫荧光法和小鼠中和试验，使针对狂犬病病毒核衣壳或糖蛋白的单克隆抗体与各种来源的疫苗株及狂犬病野外分离株发生反应。主要抗原决定簇可对病毒进行分组，次要抗原决定簇则可区分病毒株。一项保护研究表明，自然界中存在某些常规疫苗无法完全保护的抗原变异体。本文首次报道了从德意志联邦共和国“进口”蝙蝠中分离出两种此类变异体。
