Daszuta A, Barrit M C, Faudon M
Dev Neurosci. 1982 Mar-Jun;5(2-3):130-42. doi: 10.1159/000112670.
Endogenous levels of tryptophan (TRP), serotonin (5-HT), 5-hydroxyindol acetic acid (5-HIAA), noradrenaline (NA) and dopamine (DA), were measured in the brain-stem and anterior regions of C57BL and BALBc mice whose ages ranged from 1 day postnatal to 12 weeks. In C57BL mice levels of NA were found to be higher in the brainstem from week 1 onwards (except at week 3), and in the anterior region from week 6 onwards than in BALBc mice. 5-HT levels were found to be higher in C57BL mice from day 1 to week 2 in the brain-stem, and in the anterior region at week 1 and from week 5 onwards, compared to BALBc. The evolution of DA levels in the anterior region shows opposite differences before and after week 3-4. Before week 3 lower levels of DA were found in C57BL mice and the reverse is observed from week 5 onwards. Moreover during the postnatal development, the variation of the different components of the serotoninergic metabolism (TRP, 5-HT, 5-HIAA) is similar to that observed in other species.
在出生后1天至12周龄的C57BL和BALBc小鼠的脑干和前部区域测量了内源性色氨酸（TRP）、血清素（5-HT）、5-羟吲哚乙酸（5-HIAA）、去甲肾上腺素（NA）和多巴胺（DA）的水平。在C57BL小鼠中，从第1周起（第3周除外）脑干中的NA水平以及从第6周起前部区域中的NA水平高于BALBc小鼠。与BALBc小鼠相比，在C57BL小鼠中，从出生第1天到第2周脑干中的5-HT水平，以及在第1周和第5周及以后前部区域中的5-HT水平更高。前部区域中DA水平在第3 - 4周前后呈现相反的差异。在第3周之前，C57BL小鼠中的DA水平较低，而从第5周起观察到相反的情况。此外，在出生后发育过程中，血清素能代谢的不同成分（TRP、5-HT、5-HIAA）的变化与在其他物种中观察到的相似。
