Daszuta A, Barrit M C
Brain Res Bull. 1982 May;8(5):477-82. doi: 10.1016/0361-9230(82)90004-1.
The serotoninergic system has been analysed in the brainstem and the forebrain of adult C57BL and BALBc mice. Endogenous 5-HT and 5-HIAA levels have also been measured in the different raphe nuclei and in the caudate nucleus and the hippocampus of these strains, using the micropunch technique and the radioenzymatic method (for 5-HT) and a new radioimmunoassay (for 5-HIAA). This investigation was performed at three times of the day: 9:00 hr; 14:00 hr; 20:00 hr to underline the differences between the strains. Most of the time, higher 5-HT and 5-HIAA levels are found in the brainstem and the raphe nuclei of the BALBc strain compared to C57BL. In the forebrain the differences are reversed, except in the caudate nucleus and the hippocampus where the levels of 5-HT are identical in the two strains. Moreover the 5-HIAA/5-HT ratio shows a higher turn-over of the amine in the C57BL strain.
已对成年C57BL和BALBc小鼠的脑干和前脑的5-羟色胺能系统进行了分析。使用微量打孔技术和放射酶法（用于5-羟色胺）以及一种新的放射免疫分析法（用于5-羟吲哚乙酸），还测定了这些品系不同中缝核、尾状核和海马中的内源性5-羟色胺和5-羟吲哚乙酸水平。这项研究在一天中的三个时间点进行：9:00；14:00；20:00，以突出品系之间的差异。大多数情况下，与C57BL相比，在BALBc品系的脑干和中缝核中发现了更高的5-羟色胺和5-羟吲哚乙酸水平。在前脑中，差异相反，除了尾状核和海马，这两个品系中5-羟色胺的水平相同。此外，5-羟吲哚乙酸/5-羟色胺比值显示C57BL品系中胺的周转率更高。
