Dictor M
Hum Pathol. 1982 Oct;13(10):930-3. doi: 10.1016/s0046-8177(82)80055-5.
Twenty-one of 22 cases of malignant mixed mesodermal tumor (including carcinosarcoma) of the ovary were found to contain periodic acid-Schiff(PAS)-positive, diastase-resistant hyaline droplets ranging in diameter from less than 1 micrometer to approximately 50 micrometers. Droplets were located both inside and outside undifferentiated mesenchymal cells, predominantly within myxomatous areas. In 13 cases, droplets also occurred in epithelial structures, including areas mimicking ovarian carcinoma. Immunoperoxidase staining for alpha-fetoprotein was consistently negative, but droplets and cell cytoplasm reacted strongly with anti-alpha 1-antitrypsin. Analysis of the structure of droplet antitrypsin may be necessary to determine the origin of the droplets themselves and the possible usefulness of serum alpha 1- antitrypsin as a tumor marker in ovarian carcinoma and malignant mixed mesodermal tumor.
在22例卵巢恶性中胚叶混合瘤（包括癌肉瘤）中，有21例被发现含有高碘酸-希夫（PAS）染色阳性、抗淀粉酶的透明滴，直径从小于1微米到约50微米不等。这些滴状物位于未分化间充质细胞内外，主要在黏液瘤区域内。在13例病例中，滴状物也出现在上皮结构中，包括类似卵巢癌的区域。甲胎蛋白的免疫过氧化物酶染色始终为阴性，但滴状物和细胞质与抗α1-抗胰蛋白酶发生强烈反应。可能需要对滴状抗胰蛋白酶的结构进行分析，以确定这些滴状物本身的来源，以及血清α1-抗胰蛋白酶作为卵巢癌和恶性中胚叶混合瘤肿瘤标志物的潜在用途。
