Marx F J, Chaussy C, Moser E
Urologe A. 1982 Jul;21(4):206-10.
Today the indication for palliative embolization of inoperable renal carcinoma is more restricted than several years ago. Reviewing 31 own palliative occlusions of the renal artery in 29 patients over a period of 5 1/2 years two main reasons for this attitude are presented: 1. Because of collateral or parasitic vascular supply of kidney tumors the occlusion of the renal arteries only results in a retarded tumor growth rate and does not seem to prolong patient survival. 2. the "postembolization syndrome" after tumor occlusion has a relatively high complication rate and lethality (20% serious side effects, 3% deaths directly related to embolization). Therefore embolization of inoperable renal carcinomas is justified only in patients whose remaining lifetime can be alleviated by this measure. Certain indications are: massive hematuria, severe local pain due to the tumor and life endangering endocrine tumor activity, e.g. hypercalcemia. Uncertain indications such as recurring but not perilous hematuria causing progressive anemia and refusal of tumor surgery should be carefully balanced against the hazards of embolization.
如今,无法手术的肾癌姑息性栓塞治疗的适应症比几年前更加严格。回顾5年半时间里对29例患者进行的31次自体肾动脉姑息性闭塞治疗,出现这种情况主要有两个原因:1. 由于肾肿瘤存在侧支或寄生血管供应,肾动脉闭塞仅导致肿瘤生长速度减缓,似乎并不能延长患者生存期。2. 肿瘤闭塞后的“栓塞后综合征”并发症发生率和致死率相对较高(严重副作用发生率为20%,直接与栓塞相关的死亡率为3%)。因此,只有对于那些通过该措施能够缓解剩余生存期的无法手术的肾癌患者,栓塞治疗才是合理的。特定适应症包括:大量血尿、肿瘤引起的严重局部疼痛以及危及生命的内分泌肿瘤活性,如高钙血症。对于复发性但不危及生命的血尿导致进行性贫血以及拒绝肿瘤手术等不确定适应症,应仔细权衡栓塞治疗的风险。