具有P物质拮抗活性的类似物（D-脯氨酸2，D-色氨酸7,9）-P物质“神经毒性”作用的免疫组织化学证据。 - Suppr

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超能文献

Immunohistochemical evidence for a "neurotoxic" action of (D-Pro2, D-Trp7,9)-substance P, an analogue with substance P antagonistic activity.

作者信息

Hökfelt T, Vincent S, Hellsten L, Rosell S, Folkers K, Markey K, Goldstein M, Cuello C

出版信息

Acta Physiol Scand. 1981 Dec;113(4):571-3. doi: 10.1111/j.1748-1716.1981.tb06943.x.

DOI:10.1111/j.1748-1716.1981.tb06943.x

PMID:6182746

Abstract

摘要

相似文献

Immunohistochemical evidence for a "neurotoxic" action of (D-Pro2, D-Trp7,9)-substance P, an analogue with substance P antagonistic activity.具有P物质拮抗活性的类似物（D-脯氨酸2，D-色氨酸7,9）-P物质“神经毒性”作用的免疫组织化学证据。

Acta Physiol Scand. 1981 Dec;113(4):571-3. doi: 10.1111/j.1748-1716.1981.tb06943.x.

In the eye (D-Pro2, D-Trp7,9)-SP is a substance P agonist, which modifies the responses to substance P, prostaglandin E1 and antidromic trigeminal nerve stimulation.在眼中，（D-脯氨酸2，D-色氨酸7,9）-P物质是一种P物质激动剂，它可改变对P物质、前列腺素E1和三叉神经逆向刺激的反应。

Acta Physiol Scand. 1983 Jan;117(1):139-44. doi: 10.1111/j.1748-1716.1983.tb07188.x.

Effects of the substance P antagonist, (D-Arg1, D-Pro2, D-Trp7,9, Leu11)-SP on the miotic response to substance P, antidromic trigeminal nerve stimulation, capsaicin, prostaglandin E1, compound 48/80 and histamine.P物质拮抗剂（D-精氨酸1、D-脯氨酸2、D-色氨酸7,9、亮氨酸11）-P对P物质、三叉神经逆向刺激、辣椒素、前列腺素E1、化合物48/80和组胺的缩瞳反应的影响。

Acta Physiol Scand. 1984 Jan;120(1):27-35. doi: 10.1111/j.1748-1716.1984.tb07369.x.

Solution conformation of Substance P antagonists-[D-Arg1, D-Trp7,9, Leu11]-SP, [D-Arg1, D-Pro2, D-Trp7,9, Leu11]-SP and [D-Pro2, D-Trp7,9]-SP by CD, NMR and MD simulations.通过圆二色光谱（CD）、核磁共振（NMR）和分子动力学（MD）模拟研究P物质拮抗剂-[D-精氨酸1，D-色氨酸7,9，亮氨酸11]-P物质、[D-精氨酸1，D-脯氨酸2，D-色氨酸7,9，亮氨酸11]-P物质和[D-脯氨酸2，D-色氨酸7,9]-P物质的溶液构象

Peptides. 2005 May;26(5):875-85. doi: 10.1016/j.peptides.2004.12.001. Epub 2005 Jan 8.

Hypoventilation and apnoea induced by the substance P antagonist [D-Pro2,D-Trp7,9]-SP in the ventrolateral rat medulla.P物质拮抗剂[D-脯氨酸2，D-色氨酸7，9]-P物质在大鼠延髓腹外侧诱发的通气不足和呼吸暂停

Acta Physiol Scand. 1988 Sep;134(1):153-4. doi: 10.1111/j.1748-1716.1988.tb08472.x.

Antagonism by (D-Pro2, D-Trp7,9)-substance P of the cerebrovascular dilatation induced by substance P.（D-脯氨酸2、D-色氨酸7,9）-P物质对P物质诱导的脑血管扩张的拮抗作用。

Acta Physiol Scand. 1982 Dec;116(4):411-6. doi: 10.1111/j.1748-1716.1982.tb07159.x.

Substance-P antagonists: effect on spontaneous and drug-induced locomotor activity in the rat.P物质拮抗剂：对大鼠自发和药物诱导的运动活动的影响

Neuropharmacology. 1987 May;26(5):419-22. doi: 10.1016/0028-3908(87)90021-9.

Electroencephalographic and behavioral assessment of intracerebroventricular somatostatin and a substance P analogue.脑室内生长抑素和P物质类似物的脑电图及行为学评估

Brain Res. 1989 Jun 12;489(2):223-30. doi: 10.1016/0006-8993(89)90854-8.

Evaluation of (D-Pro2, D-Trp7,9)-substance P as an antagonist of substance P responses in the rat central nervous system.评估（D-脯氨酸2，D-色氨酸7,9）-P物质作为大鼠中枢神经系统中P物质反应拮抗剂的作用。

Neurosci Lett. 1982 Jun 30;30(3):291-5. doi: 10.1016/0304-3940(82)90415-3.

Species differences in the behavioral toxicity produced by intrathecal substance P antagonists: relationship to analgesia.

Life Sci. 1987 Jan 12;40(2):175-81. doi: 10.1016/0024-3205(87)90357-2.

引用本文的文献

Higher potency of RP 67580, in the mouse and the rat compared with other nonpeptide and peptide tachykinin NK1 antagonists.与其他非肽类和肽类速激肽NK1拮抗剂相比，RP 67580在小鼠和大鼠中具有更高的效价。

Br J Pharmacol. 1993 Mar;108(3):793-800. doi: 10.1111/j.1476-5381.1993.tb12880.x.

Intranigral application of substance P antagonists prevents the haloperidol-induced activation of striatal tyrosine hydroxylase.

Naunyn Schmiedebergs Arch Pharmacol. 1984 May;326(1):83-6. doi: 10.1007/BF00518784.

Capsaicin-induced reflex fall in rat blood pressure is mediated by afferent substance P-containing neurones via a reflex centre in the brain stem.辣椒素引起的大鼠血压反射性下降是由含P物质的传入神经元通过脑干中的反射中枢介导的。

Naunyn Schmiedebergs Arch Pharmacol. 1983 Dec;324(4):293-5. doi: 10.1007/BF00502626.

Substance P is a functional neurotransmitter in the rat parotid gland.P物质是大鼠腮腺中的一种功能性神经递质。

J Physiol. 1983 Sep;342:483-98. doi: 10.1113/jphysiol.1983.sp014864.

Immunohistochemical and behavioral analysis of spinal lesions induced by a substance P antagonist and protection by thyrotropin releasing hormone.P物质拮抗剂诱导的脊髓损伤的免疫组织化学和行为分析以及促甲状腺激素释放激素的保护作用

Exp Brain Res. 1989;74(2):279-92. doi: 10.1007/BF00248861.

Autonomic, sensory, and motor dysfunction following intrathecal administration of three substance P antagonists.

Exp Brain Res. 1988;70(1):61-72. doi: 10.1007/BF00271848.

Thyrotropin-releasing hormone (TRH) counteracts neuronal damage induced by a substance P antagonist.促甲状腺激素释放激素（TRH）可对抗P物质拮抗剂诱导的神经元损伤。

Exp Brain Res. 1986;62(1):175-8. doi: 10.1007/BF00237413.

Substance P antagonists and mucociliary activity in rabbit.

Naunyn Schmiedebergs Arch Pharmacol. 1985 Jun;329(4):376-81. doi: 10.1007/BF00496371.

The effects of substance P analogues on the scratching, biting and licking response induced by intrathecal injection of N-methyl-D-aspartate in mice.P物质类似物对小鼠鞘内注射N-甲基-D-天冬氨酸诱导的抓挠、啃咬和舔舐反应的影响。

Br J Pharmacol. 1990 Oct;101(2):307-10. doi: 10.1111/j.1476-5381.1990.tb12706.x.

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