Azzopardi J G, Muretto P, Goddeeris P, Eusebi V, Lauweryns J M
Histopathology. 1982 Sep;6(5):549-69. doi: 10.1111/j.1365-2559.1982.tb02750.x.
Fourteen 'carcinoid' tumours of the breast are described. They are separable into five with and nine without intracellular mucin. All the tumours are argyrophil, but none is argentaffin. Four tumours studied ultrastructurally contain dense-core granules. Argyrophil carcinomas represent the endocrine analogues of ductal carcinoma in situ, of invasive ductal carcinoma and probably of lobular carcinoma also. Current views vary between the one that the so-called carcinoid is a rare and totally distinct entity to the view, at the other extreme, that it is a very common variant of conventional breast cancer. On the basis of our findings, an intermediate view is justified: argyrophil carcinomas constitute about 5% of breast carcinomas and some varieties at least have non-argyrophil analogues. Factors influencing the prognosis in individual cases are discussed. Argyrophil carcinomas of the breast form a tumour spectrum with a wide range of morphological and histochemical appearances and a variable prognosis.
本文描述了14例乳腺“类癌”肿瘤。它们可分为5例有细胞内黏液的和9例无细胞内黏液的。所有肿瘤均嗜银，但无亲银性。经超微结构研究的4例肿瘤含有致密核心颗粒。嗜银性癌代表原位导管癌、浸润性导管癌以及可能的小叶癌的内分泌类似物。目前的观点差异很大，一种观点认为所谓的类癌是一种罕见且完全不同的实体，而另一种极端观点则认为它是传统乳腺癌非常常见的变体。基于我们的研究结果，一种折中的观点是合理的：嗜银性癌约占乳腺癌的5%，并且至少某些类型有非嗜银性的类似物。文中讨论了影响个别病例预后的因素。乳腺嗜银性癌形成了一个具有广泛形态学和组织化学表现以及可变预后的肿瘤谱。
