Horai S, van der Poel J J, Goulmy E
Immunogenetics. 1982;16(2):135-42. doi: 10.1007/BF00364400.
Human alloimmune cytotoxic T cells, sensitized selectively against the HLA-A2 antigen, were tested on a panel of selected target cells. Five HLA-A2 positive outlier cells could be identified. These outlier cells were only weakly lysed by HLA-A2 specific CTLs, although they were serologically indistinguishable from the other HLA-A2 positive, strongly lysed target cells. Furthermore, it was found that the outlier cells were poor cold target inhibitors in contrast to the other HLA-A2 positive target cells, which showed adequate inhibition of specific lysis of HLA-A2 positive target cells. Population studies indicate that the frequency of such HLA-A2 outlier cells may be approximately 10%.
对一组选定的靶细胞检测了选择性针对HLA - A2抗原致敏的人同种异体免疫细胞毒性T细胞。可以鉴定出五个HLA - A2阳性异常细胞。尽管这些异常细胞在血清学上与其他HLA - A2阳性且被强烈裂解的靶细胞无法区分，但它们仅被HLA - A2特异性CTLs轻微裂解。此外，发现与其他HLA - A2阳性靶细胞相比，异常细胞是较差的冷靶抑制剂，其他HLA - A2阳性靶细胞对HLA - A2阳性靶细胞的特异性裂解有充分的抑制作用。群体研究表明，此类HLA - A2异常细胞的频率可能约为10%。
