Gustafsson B, Rosén A, Holme T
Infect Immun. 1982 Nov;38(2):449-54. doi: 10.1128/iai.38.2.449-454.1982.
A cell line producing monoclonal antibodies directed against the core region of Vibrio cholerae lipopolysaccharide has been established. These antibodies were inhibited by lipopolysaccharide preparations of both O-group 1 vibrios and some non-O-group 1 vibrios as detected in enzyme-linked immunosorbent assay-inhibition experiments. Coagglutination experiments with monoclonal and polyclonal antibodies adsorbed to protein A-carrying staphylococci were performed. All V. cholerae strains tested, regardless of serotype, were agglutinated when mixed with staphylococci coated with the monoclonal antibodies, whereas staphylococci coated with group-specific (O1) polyclonal antibodies only agglutinated with O-group 1 vibrios.
已建立了一种产生针对霍乱弧菌脂多糖核心区域的单克隆抗体的细胞系。在酶联免疫吸附测定抑制实验中检测到，这些抗体被1群霍乱弧菌和一些非1群霍乱弧菌的脂多糖制剂所抑制。进行了用吸附到携带蛋白A的葡萄球菌上的单克隆和多克隆抗体的协同凝集实验。所有测试的霍乱弧菌菌株，无论血清型如何，与包被有单克隆抗体的葡萄球菌混合时都会发生凝集，而包被有群特异性（O1）多克隆抗体的葡萄球菌仅与1群霍乱弧菌发生凝集。
