Sanchez Y, Ionescu-Matiu I I, Sparrow J T, Melnick J L, Dreesman G R
Intervirology. 1982;18(4):209-13. doi: 10.1159/000149327.
A cyclic peptide containing the amino acid sequence 122 through 137 of the major hepatitis B surface antigen (HBsAg) polypeptide was synthesized. The immunogenicity of this synthetic peptide, aggregated in micelles or covalently coupled to tetanus toxoid, was assessed in mice. Antibodies against HBsAg (anti-HBs) were obtained with both preparations, administered either in saline suspension or adsorbed on aluminum gel. The peptide-tetanus toxoid conjugate was more immunogenic than the peptide micelles, producing high levels of specific anti-HBs.
合成了一种包含乙型肝炎表面抗原（HBsAg）主要多肽122至137位氨基酸序列的环肽。在小鼠中评估了这种合成肽在胶束中聚集或与破伤风类毒素共价偶联后的免疫原性。两种制剂均获得了抗HBsAg抗体（抗-HBs），它们以生理盐水悬浮液形式给药或吸附在铝胶上。肽-破伤风类毒素偶联物比肽胶束具有更强的免疫原性，可产生高水平的特异性抗-HBs。
