一种环状合成肽对常见人类抗乙型肝炎表面抗原独特型的抑制作用。
Inhibition of a common human anti-hepatitis B surface antigen idiotype by a cyclic synthetic peptide.
作者信息
Kennedy R C, Dreesman G R, Sparrow J T, Culwell A R, Sanchez Y, Ionescu-Matiu I, Hollinger F B, Melnick J L
出版信息
J Virol. 1983 May;46(2):653-5. doi: 10.1128/JVI.46.2.653-655.1983.
Abstract
A common human anti-hepatitis B surface antigen idiotype-anti-idiotype reaction was partially inhibited by a cyclic synthetic hepatitis B surface antigen peptide. Reduction of the intrachain disulfide bond and subsequent alkylation destroyed its inhibitory activity, suggesting that a conformation-dependent group alpha epitope was associated with this cyclic peptide.
摘要
一种常见的人抗乙型肝炎表面抗原独特型-抗独特型反应被一种环状合成乙型肝炎表面抗原肽部分抑制。链内二硫键的还原及随后的烷基化破坏了其抑制活性，这表明一种构象依赖性的α基团表位与该环状肽相关。
相似文献
1
Inhibition of a common human anti-hepatitis B surface antigen idiotype by a cyclic synthetic peptide.一种环状合成肽对常见人类抗乙型肝炎表面抗原独特型的抑制作用。
J Virol. 1983 May;46(2):653-5. doi: 10.1128/JVI.46.2.653-655.1983.
2
Epitopes associated with a synthetic hepatitis B surface antigen peptide.与合成乙肝表面抗原肽相关的表位
J Immunol. 1983 Apr;130(4):1947-52.
3
Antigen mimicry by anti-idiotype antibodies that recognize a common anti-hepatitis B surface antigen idiotype.
Adv Exp Med Biol. 1985;185:139-47. doi: 10.1007/978-1-4684-7974-4_9.
4
Common idiotypic determinant associated with human antibodies to hepatitis B surface antigen.与人类抗乙型肝炎表面抗原抗体相关的共同独特型决定簇。
J Immunol. 1983 Jan;130(1):385-9.
5
Antibody to hepatitis B virus induced by injecting antibodies to the idiotype.通过注射抗独特型抗体诱导产生的抗乙型肝炎病毒抗体。
Science. 1984 Mar 2;223(4639):930-1. doi: 10.1126/science.6198721.
6
Enhancement of viral hepatitis B antibody (Anti-HBs) response to a synthetic cyclic peptide by priming with anti-idiotype antibodies.通过用抗独特型抗体进行初免增强对合成环肽的乙型肝炎病毒抗体（抗-HBs）反应。
Virology. 1984 Jul 15;136(1):247-52. doi: 10.1016/0042-6822(84)90264-2.
7
Immune response to hepatitis B surface antigen: enhancement by prior injection of antibodies to the idiotype.对乙型肝炎表面抗原的免疫反应：通过预先注射抗独特型抗体增强。
Science. 1983 Aug 26;221(4613):853-5. doi: 10.1126/science.6603657.
8
Synthetic hepatitis B surface antigen peptide vaccine.合成乙肝表面抗原肽疫苗。
Adv Exp Med Biol. 1985;185:129-37. doi: 10.1007/978-1-4684-7974-4_8.
9
Immunological evaluation of three generations of anti-idiotype vaccine: study of B and T cell responses following priming with anti-idiotype, anti-idiotype peptide and its MAP structure.三代抗独特型疫苗的免疫学评估：用抗独特型、抗独特型肽及其MAP结构进行初次免疫后B细胞和T细胞反应的研究
Vaccine. 1995;13(15):1421-6. doi: 10.1016/0264-410x(95)00072-9.
10
Anti-idiotype antibody as a prospective vaccine against hepatitis B.抗独特型抗体作为一种潜在的乙型肝炎疫苗。
Folia Biol (Praha). 1987;33(2):98-103.
引用本文的文献
1
Enhancement of the immune response to hepatitis B surface antigen. In vivo administration of antiidiotype induces anti-HBs that expresses a similar idiotype.增强对乙型肝炎表面抗原的免疫反应。抗独特型抗体的体内给药可诱导表达相似独特型的抗-HBs。
J Exp Med. 1984 Mar 1;159(3):655-65. doi: 10.1084/jem.159.3.655.
2
Hepatitis B virus infection. Current concepts of chronicity and immunity.乙型肝炎病毒感染。慢性化与免疫的当前概念。
West J Med. 1984 May;140(5):754-62.
3
Expression of immunogenic epitopes of hepatitis B surface antigen with hybrid flagellin proteins by a vaccine strain of Salmonella.沙门氏菌疫苗株利用杂合鞭毛蛋白表达乙型肝炎表面抗原的免疫原性表位
Proc Natl Acad Sci U S A. 1989 Jun;86(12):4726-30. doi: 10.1073/pnas.86.12.4726.
本文引用的文献
1
Isolation and characterization of the major protein and glycoprotein of hepatitis B surface antigen.乙型肝炎表面抗原主要蛋白质和糖蛋白的分离与特性鉴定
J Biol Chem. 1981 Jul 10;256(13):6975-83.
2
Immunization of chimpanzees with hepatitis B virus-derived polypeptides.用乙型肝炎病毒衍生多肽对黑猩猩进行免疫接种。
Infect Immun. 1981 Apr;32(1):62-7. doi: 10.1128/iai.32.1.62-67.1981.
3
Type B hepatitis: a review of current prospects for a safe and effective vaccine.乙型肝炎：安全有效疫苗当前前景综述
Rev Infect Dis. 1980 May-Jun;2(3):470-92. doi: 10.1093/clinids/2.3.470.
4
Biology of hepatitis B virus.乙型肝炎病毒生物学
Science. 1981 Jul 24;213(4506):406-11. doi: 10.1126/science.6264599.
5
Expression of the hepatitis B virus surface antigen gene in cell culture by using a simian virus 40 vector.利用猿猴病毒40载体在细胞培养中表达乙型肝炎病毒表面抗原基因。
Proc Natl Acad Sci U S A. 1981 Apr;78(4):2606-10. doi: 10.1073/pnas.78.4.2606.
6
Common idiotypic determinant associated with human antibodies to hepatitis B surface antigen.与人类抗乙型肝炎表面抗原抗体相关的共同独特型决定簇。
J Immunol. 1983 Jan;130(1):385-9.
7
Immunogenicity of conjugates and micelles of synthetic hepatitis B surface antigen peptides.合成乙肝表面抗原肽的缀合物与胶束的免疫原性
Intervirology. 1982;18(4):209-13. doi: 10.1159/000149327.
8
Immune response to synthetic peptide analogues of hepatitis B surface antigen specific for the a determinant.针对乙型肝炎表面抗原 a 决定簇特异性合成肽类似物的免疫反应。
Proc Natl Acad Sci U S A. 1982 Jul;79(14):4400-4. doi: 10.1073/pnas.79.14.4400.
9
Hepatitis B virus vaccine: identification of HBsAg/a and HBsAg/d but not HBsAg/y subtype antigenic determinants on a synthetic immunogenic peptide.乙肝病毒疫苗：在一种合成免疫原性肽上鉴定出 HBsAg/a 和 HBsAg/d 但未鉴定出 HBsAg/y 亚型抗原决定簇。
Proc Natl Acad Sci U S A. 1982 Jan;79(2):579-82. doi: 10.1073/pnas.79.2.579.
10
Antibody to hepatitis B surface antigen after a single inoculation of uncoupled synthetic HBsAg peptides.单次接种未偶联的合成乙肝表面抗原肽后产生的乙肝表面抗原抗体
Nature. 1982 Jan 14;295(5845):158-60. doi: 10.1038/295158a0.
Zotero 插件