一种环状合成肽对常见人类抗乙型肝炎表面抗原独特型的抑制作用。
Inhibition of a common human anti-hepatitis B surface antigen idiotype by a cyclic synthetic peptide.
作者信息
Kennedy R C, Dreesman G R, Sparrow J T, Culwell A R, Sanchez Y, Ionescu-Matiu I, Hollinger F B, Melnick J L
出版信息
J Virol. 1983 May;46(2):653-5. doi: 10.1128/JVI.46.2.653-655.1983.
Abstract
A common human anti-hepatitis B surface antigen idiotype-anti-idiotype reaction was partially inhibited by a cyclic synthetic hepatitis B surface antigen peptide. Reduction of the intrachain disulfide bond and subsequent alkylation destroyed its inhibitory activity, suggesting that a conformation-dependent group alpha epitope was associated with this cyclic peptide.
摘要
一种常见的人抗乙型肝炎表面抗原独特型-抗独特型反应被一种环状合成乙型肝炎表面抗原肽部分抑制。链内二硫键的还原及随后的烷基化破坏了其抑制活性，这表明一种构象依赖性的α基团表位与该环状肽相关。
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本文引用的文献
1
Isolation and characterization of the major protein and glycoprotein of hepatitis B surface antigen.
J Biol Chem. 1981 Jul 10;256(13):6975-83.
2
Immunization of chimpanzees with hepatitis B virus-derived polypeptides.
Infect Immun. 1981 Apr;32(1):62-7. doi: 10.1128/iai.32.1.62-67.1981.
3
Type B hepatitis: a review of current prospects for a safe and effective vaccine.
Rev Infect Dis. 1980 May-Jun;2(3):470-92. doi: 10.1093/clinids/2.3.470.
4
Biology of hepatitis B virus.
Science. 1981 Jul 24;213(4506):406-11. doi: 10.1126/science.6264599.
5
Expression of the hepatitis B virus surface antigen gene in cell culture by using a simian virus 40 vector.
Proc Natl Acad Sci U S A. 1981 Apr;78(4):2606-10. doi: 10.1073/pnas.78.4.2606.
6
Common idiotypic determinant associated with human antibodies to hepatitis B surface antigen.
J Immunol. 1983 Jan;130(1):385-9.
7
Immunogenicity of conjugates and micelles of synthetic hepatitis B surface antigen peptides.
Intervirology. 1982;18(4):209-13. doi: 10.1159/000149327.
8
Immune response to synthetic peptide analogues of hepatitis B surface antigen specific for the a determinant.
Proc Natl Acad Sci U S A. 1982 Jul;79(14):4400-4. doi: 10.1073/pnas.79.14.4400.
9
Hepatitis B virus vaccine: identification of HBsAg/a and HBsAg/d but not HBsAg/y subtype antigenic determinants on a synthetic immunogenic peptide.
Proc Natl Acad Sci U S A. 1982 Jan;79(2):579-82. doi: 10.1073/pnas.79.2.579.
10
Antibody to hepatitis B surface antigen after a single inoculation of uncoupled synthetic HBsAg peptides.
Nature. 1982 Jan 14;295(5845):158-60. doi: 10.1038/295158a0.
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