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单克隆抗体在人类恶性肿瘤组织病理学诊断中的应用。

Use of monoclonal antibodies for the histopathological diagnosis of human malignancy.

作者信息

Gatter K C, Abdulaziz Z, Beverley P, Corvalan J R, Ford C, Lane E B, Mota M, Nash J R, Pulford K, Stein H, Taylor-Papadimitriou J, Woodhouse C, Mason D Y

出版信息

J Clin Pathol. 1982 Nov;35(11):1253-67. doi: 10.1136/jcp.35.11.1253.

DOI:10.1136/jcp.35.11.1253
PMID:6183295
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC497939/
Abstract

This paper describes the use of a panel of seven monoclonal antibodies (selected so as to include reagents reactive with both epithelial and lymphoid cells) for distinguishing between anaplastic carcinoma and high grade lymphoma. Details are given of the immunohistological reactions of these antibodies against a wide range of both normal and malignant tissues and of a number of practical instances in which use of the antibody panel enabled a diagnosis to be made when routine histological examination had been inconclusive.

摘要

本文描述了使用一组七种单克隆抗体（其选择方式是包括与上皮细胞和淋巴细胞均有反应的试剂）来区分间变性癌和高级别淋巴瘤。文中给出了这些抗体针对多种正常和恶性组织的免疫组织学反应的详细信息，以及一些实际案例，即在常规组织学检查无法得出结论时，使用该抗体组能够做出诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d15b/497939/68c6eb50af57/jclinpath00504-0095-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d15b/497939/945e71400aa0/jclinpath00504-0094-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d15b/497939/23330537c496/jclinpath00504-0088-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d15b/497939/4857b8a3c64a/jclinpath00504-0089-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d15b/497939/7a959c9ae866/jclinpath00504-0089-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d15b/497939/0cf23f515dc6/jclinpath00504-0090-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d15b/497939/d9e851869c19/jclinpath00504-0091-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d15b/497939/b46e56789036/jclinpath00504-0093-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d15b/497939/68c6eb50af57/jclinpath00504-0095-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d15b/497939/945e71400aa0/jclinpath00504-0094-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d15b/497939/23330537c496/jclinpath00504-0088-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d15b/497939/4857b8a3c64a/jclinpath00504-0089-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d15b/497939/7a959c9ae866/jclinpath00504-0089-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d15b/497939/0cf23f515dc6/jclinpath00504-0090-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d15b/497939/d9e851869c19/jclinpath00504-0091-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d15b/497939/b46e56789036/jclinpath00504-0093-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d15b/497939/68c6eb50af57/jclinpath00504-0095-a.jpg

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本文引用的文献

1
Monoclonal antibodies to epithelium-specific components of the human milk fat globule membrane: production and reaction with cells in culture.针对人乳脂肪球膜上皮特异性成分的单克隆抗体：制备及其与培养细胞的反应
Int J Cancer. 1981 Jul 15;28(1):17-21. doi: 10.1002/ijc.2910280104.
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Graft-versus-host disease induces expression of Ia antigen in rat epidermal cells and gut epithelium.移植物抗宿主病可诱导大鼠表皮细胞和肠道上皮细胞表达Ia抗原。
Nature. 1981;293(5828):150-1. doi: 10.1038/293150a0.
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Expression of Ia antigen on epidermal keratinocytes in graft-versus-host disease.
Int J Nanomedicine. 2013;8:2629-40. doi: 10.2147/IJN.S47279. Epub 2013 Jul 24.
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Newer developments in immunohistology.免疫组织学的最新进展。
J Clin Pathol. 2006 Nov;59(11):1117-26. doi: 10.1136/jcp.2005.031179.
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Expression of HLA-DR antigens by colonic epithelium in inflammatory bowel disease.炎症性肠病中结肠上皮细胞 HLA-DR 抗原的表达
Clin Exp Immunol. 1983 Sep;53(3):614-8.
6
Immunohistochemical reactivity of a monoclonal antibody prepared against human breast carcinoma.针对人乳腺癌制备的单克隆抗体的免疫组织化学反应性。
Virchows Arch A Pathol Anat Histopathol. 1984;402(4):389-404. doi: 10.1007/BF00734636.
7
Monoclonal antibodies in the treatment of cancer: preliminary observations and future prospects.单克隆抗体在癌症治疗中的应用：初步观察与未来展望。
Med Oncol Tumor Pharmacother. 1984;1(2):51-62. doi: 10.1007/BF02934975.
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Monoclonal antibodies as reagents for brain tumour diagnosis: a review.单克隆抗体作为脑肿瘤诊断试剂的综述
J R Soc Med. 1984 Sep;77(9):780-7. doi: 10.1177/014107688407700914.
9
Nature of non-B, non-T lymphomas: an immunohistological study on frozen tissues using monoclonal antibodies.非B非T淋巴瘤的性质：使用单克隆抗体对冷冻组织进行的免疫组织学研究。
J Clin Pathol. 1984 Aug;37(8):911-8. doi: 10.1136/jcp.37.8.911.
10
The immunocytochemical detection of axillary micrometastases in breast cancer.乳腺癌腋窝微转移的免疫细胞化学检测
Br J Cancer. 1984 Aug;50(2):193-7. doi: 10.1038/bjc.1984.162.
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Nature. 1981;293(5828):149-50. doi: 10.1038/293149a0.
4
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Ia-like (HLA-DR) antigens in the diagnosis of lymphoma and undifferentiated tumors.
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