Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.
Cells. 2022 Jan 5;11(1):174. doi: 10.3390/cells11010174.
David Mason started his research career at a time when lymphoma diagnosis was based primarily on cellular morphology, clinical symptoms and special cytochemical stains using formalin fixed tissue sections. There were occasions, however, where the morphology was unhelpful, such as in the case of anaplastic or poorly differentiated tumours, where a distinction between lymphoma and a non-haematopoietic tumour was often problematical. Accurate diagnosis became even more important with the developments in the clinical staging of lymphoma and the availability of more effective treatments. One way forward to improve diagnosis was to use immunohistochemistry to study the antigens expressed by the tumor cells.
戴维·梅森 (David Mason) 在淋巴瘤的诊断主要基于细胞形态、临床症状和使用福尔马林固定组织切片的特殊细胞化学染色的时代开始了他的研究生涯。然而，有时形态学并没有帮助，例如在间变性或低分化肿瘤的情况下，淋巴瘤和非造血肿瘤之间的区分通常是有问题的。随着淋巴瘤临床分期的发展和更有效的治疗方法的出现，准确诊断变得更加重要。提高诊断水平的一种方法是使用免疫组织化学来研究肿瘤细胞表达的抗原。
