Befus A D, Pearce F L, Goodacre R, Bienenstock J
Adv Exp Med Biol. 1982;149:521-7. doi: 10.1007/978-1-4684-9066-4_73.
Mast cells have been isolated from the intestine (IMC) of rats previously infected with the nematode, Nippostrongylus brasiliensis. Functional studies on IMC have shown that they are responsive to antigen and possess surface IgE but, in contrast to peritoneal mast cells (PMC), IMC are unresponsive to the basic secretagogues, 48/80 and bee venom peptide 401, and hyporesponsive to ionophores. Furthermore, sodium cromoglycate, AH9679 and theophylline inhibited secretion by PMC but not IMC, whereas doxantrazole inhibited secretion by both cells. Histochemical investigations established that there is mast cell heterogeneity in the human intestine as well as in the rat. Since GALT and BALT are important in intestinal mastocytosis it is important to determine whether the distinct functional properties of IMC reflect a distinct precursor population, inducer cell, or other factors in GALT or BALT.
肥大细胞已从先前感染过巴西日圆线虫的大鼠肠道（肠肥大细胞，IMC）中分离出来。对肠肥大细胞的功能研究表明，它们对抗原具有反应性并拥有表面免疫球蛋白E，但与腹膜肥大细胞（PMC）不同的是，肠肥大细胞对碱性促分泌剂48/80和蜂毒肽401无反应，对离子载体反应低下。此外，色甘酸钠、AH9679和茶碱可抑制腹膜肥大细胞的分泌，但对肠肥大细胞无作用，而多沙唑可抑制两种细胞的分泌。组织化学研究证实，人类肠道以及大鼠体内存在肥大细胞异质性。由于肠道相关淋巴组织（GALT）和支气管相关淋巴组织（BALT）在肠道肥大细胞增多症中起重要作用，因此确定肠肥大细胞独特的功能特性是否反映了GALT或BALT中不同的前体细胞群、诱导细胞或其他因素非常重要。
