Shanahan F, Lee T D, Bienenstock J, Befus A D
Int Arch Allergy Appl Immunol. 1986;80(4):424-6. doi: 10.1159/000234092.
Increasing evidence suggests that neuropeptides may be important stimuli for mast cell secretion. Neuropeptide-induced histamine secretion from rat mast cells was inhibited by a variety of clinical and experimental antiallergic agents. The profile of responsiveness to this panel of drugs exhibited by peritoneal (PMC) and intestinal mucosal mast cells (IMC) was similar to that previously reported when histamine release was immunologically induced. Thus, cromoglycate, theophylline and Ro 22-3747 inhibited peptide-induced secretion from PMC but not from IMC. In contrast, doxantrazole was effective against PMC and IMC. Differences between IMC and PMC could not be attributed to the IMC isolation procedure. The results confirm the heterogeneity of responsiveness to antiallergic drugs exhibited by these mast cell subpopulations and indicate that it is not limited to immunologically induced secretion but also occurs when a neuropeptide is the secretory stimulus.
越来越多的证据表明，神经肽可能是肥大细胞分泌的重要刺激物。多种临床和实验性抗过敏药物可抑制神经肽诱导的大鼠肥大细胞组胺分泌。腹膜肥大细胞（PMC）和肠黏膜肥大细胞（IMC）对这组药物的反应特性与先前报道的免疫诱导组胺释放时相似。因此，色甘酸、茶碱和Ro 22 - 3747可抑制PMC中肽诱导的分泌，但对IMC无效。相比之下，多沙唑嗪对PMC和IMC均有效。IMC和PMC之间的差异不能归因于IMC的分离程序。结果证实了这些肥大细胞亚群对抗过敏药物反应的异质性，并表明这种异质性不仅限于免疫诱导的分泌，当神经肽作为分泌刺激物时也会出现。
