某些Ia同种异型与慢性淋巴细胞白血病发生的关联。一种单克隆抗Ia试剂对DR系列以外的易感性决定簇的识别。
Association of certain Ia allotypes with the occurrence of chronic lymphocytic leukemia. Recognition by a monoclonal anti-Ia reagent of a susceptibility determinant not in the DR series.
作者信息
Nunez-Roldan A, Szer I, Toguchi T, Cuttner J, Winchester R
出版信息
J Exp Med. 1982 Dec 1;156(6):1872-7. doi: 10.1084/jem.156.6.1872.
Abstract
The Ia antigen allospecificities of individuals with B type chronic lymphocytic leukemia differed significantly from those of a control population. A monoclonal antibody, IVD12, directed to a MB3-1ike determinant, reacted with 92.5 percent of the individuals with leukemia and yielded the greatest positive relative risk, 13.5. A lower degree of positive association was found with the presence of the MT2 determinant. In contrast, the low observed frequency of the MT1/MB1 determinant among leukemic individuals was associated with the most significant negative relative risk, -8.1. Among HLA- DR specificities, the relative risk associated with the presence of DR5 was positive while that with DR2 was negative.
摘要
B型慢性淋巴细胞白血病患者的Ia抗原同种特异性与对照人群有显著差异。一种针对MB3样决定簇的单克隆抗体IVD12，与92.5%的白血病患者发生反应，并产生了最大的阳性相对风险，即13.5。MT2决定簇的存在与之呈较低程度的正相关。相反，白血病患者中MT1/MB1决定簇的低观察频率与最显著的阴性相对风险相关，即 -8.1。在HLA-DR特异性中，与DR5存在相关的相对风险为阳性，而与DR2相关的相对风险为阴性。
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