铜绿假单胞菌多糖的交叉保护作用。
Cross-protection by Pseudomonas aeruginosa polysaccharides.
作者信息
Pier G B
出版信息
Infect Immun. 1982 Dec;38(3):1117-22. doi: 10.1128/iai.38.3.1117-1122.1982.
Abstract
High-molecular-weight polysaccharide from Pseudomonas aeruginosa immunotypes 1 and 2 gave cross-protection in outbred CD-1 mice challenged with the heterologous immunotype organism. Both active immunization with 50 micrograms of polysaccharide, as well as passive transfer of immune serum were effective. The basis for this cross-protection is the ability of high doses of polysaccharide to induce antibody formation to both homologous and heterologous immunotype determinants.
摘要
来自铜绿假单胞菌免疫型1和2的高分子量多糖，在受到异源免疫型菌株攻击的远交系CD-1小鼠中提供了交叉保护。用50微克多糖进行主动免疫以及免疫血清的被动转移均有效。这种交叉保护的基础是高剂量多糖诱导针对同源和异源免疫型决定簇产生抗体形成的能力。
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