用铜绿假单胞菌高分子量多糖进行免疫可预防小鼠因铜绿假单胞菌烧伤感染而死亡。
Immunization with Pseudomonas aeruginosa high-molecular-weight polysaccharides prevents death from Pseudomonas burn infections in mice.
作者信息
Pollack M, Pier G B, Prescott R K
出版信息
Infect Immun. 1984 Feb;43(2):759-60. doi: 10.1128/iai.43.2.759-760.1984.
Abstract
High-molecular-weight polysaccharides from the extracellular slime of Pseudomonas aeruginosa were evaluated as immunogens in Pseudomonas burn infections in mice. Immunization with immunotype 1 or 2 polysaccharides induced a strong immunotype-specific and weak cross-reactive antibody response but protected mice against burn infections caused by either immunotype. Passive protection was provided by rabbit antiserum to immunotype 1 polysaccharide against burn infection by the homologous organism. Pseudomonas high-molecular-weight polysaccharides are potentially effective vaccines in burn infections.
摘要
对来自铜绿假单胞菌胞外黏液的高分子量多糖作为小鼠铜绿假单胞菌烧伤感染中的免疫原进行了评估。用1型或2型多糖免疫诱导了强烈的免疫型特异性和弱交叉反应性抗体应答，但能保护小鼠免受由任一免疫型引起的烧伤感染。兔抗1型多糖血清为同源菌株引起的烧伤感染提供了被动保护。铜绿假单胞菌高分子量多糖在烧伤感染中可能是有效的疫苗。
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