阿昔洛韦与免疫转移对小鼠新生儿单纯疱疹病毒感染的相加作用。
Additive effects of acyclovir and immune transfer in neonatal herpes simplex virus infection in mice.
作者信息
Kohl S
出版信息
Infect Immun. 1983 Jan;39(1):480-2. doi: 10.1128/iai.39.1.480-482.1983.
Abstract
Acyclovir had a dose-dependent, mild, but significant, inhibitory effect on interferon-stimulated human antiviral natural killer cytotoxicity in vitro. In a murine model of neonatal herpes simplex virus infection, acyclovir significantly (P < 0.05) increased survival afforded by the injection of human interferon and human mononuclear leukocytes from 67.8 to 88.6%.
摘要
阿昔洛韦在体外对干扰素刺激的人抗病毒自然杀伤细胞毒性具有剂量依赖性、轻度但显著的抑制作用。在新生儿单纯疱疹病毒感染的小鼠模型中，阿昔洛韦显著（P<0.05）提高了注射人干扰素和人单核白细胞后的存活率，从67.8%提高到88.6%。
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Protective T-cell-based immunity induced in neonatal mice by a single replicative cycle of herpes simplex virus.单纯疱疹病毒的单个复制周期在新生小鼠中诱导产生的基于T细胞的保护性免疫。
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本文引用的文献
1
Natural killer cells: their roles in defenses against disease.自然杀伤细胞：它们在抵御疾病中的作用。
Science. 1981 Oct 2;214(4516):24-30. doi: 10.1126/science.7025208.
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Vidarabine therapy of neonatal herpes simplex virus infection.新生儿单纯疱疹病毒感染的阿糖腺苷治疗
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Ontogeny of murine cellular cytotoxicity to herpes simplex virus-infected cells.小鼠对单纯疱疹病毒感染细胞的细胞毒性个体发生。
Infect Immun. 1980 Dec;30(3):847-50. doi: 10.1128/iai.30.3.847-850.1980.
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Drug therapy: antiviral agents (second of two parts).药物治疗：抗病毒药物（两部分中的第二部分）
N Engl J Med. 1980 Apr 24;302(17):949-53. doi: 10.1056/NEJM198004243021705.
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Interferon induction of natural killer cytotoxicity in human neonates.干扰素诱导人类新生儿自然杀伤细胞的细胞毒性
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