Kohl S, Loo L S
Infect Immun. 1980 Dec;30(3):847-50. doi: 10.1128/iai.30.3.847-850.1980.
Mice infected with herpes simplex virus either orally or intraperitoneally had a markedly age-related mortality. All animals under 3 weeks of age died, whereas all those over 3 weeks of age survived. The ability of murine peritoneal cells to kill herpes simplex virus-infected target cells in the absence (natural killer cytotoxicity) or presence (antibody-dependent cellular cytotoxicity) of antiviral antibody was similarly correlated with age and survival. This correlation is further support for the relevance of these antiviral defense mechanisms, and it may help explain the profound susceptibility of neonatal mice to herpes simplex virus infection.
经口或腹腔感染单纯疱疹病毒的小鼠具有明显的年龄相关性死亡率。所有3周龄以下的动物均死亡，而所有3周龄以上的动物均存活。在不存在抗病毒抗体（自然杀伤细胞细胞毒性）或存在抗病毒抗体（抗体依赖性细胞毒性）的情况下，小鼠腹腔细胞杀死单纯疱疹病毒感染靶细胞的能力同样与年龄和存活率相关。这种相关性进一步支持了这些抗病毒防御机制的相关性，并且可能有助于解释新生小鼠对单纯疱疹病毒感染的高度易感性。
