Hanafy M S, Bogan J A
Vet Res Commun. 1982 Nov;5(4):355-61. doi: 10.1007/BF02215005.
Strips of smooth muscle from the pulmonary vein, pulmonary artery, trachea and bronchus of calves were incubated in an organ bath with 3-methylindole (3MI) and 3-methyloxindole (3MOI). 3MI and 3MOI (5-640 micrograms/ml) did not cause contraction of any of the isolated smooth muscle preparations. No evidence for the release of mediators of anaphylaxis was obtained when chopped bovine lung preparations were incubated with 3MI (20 micrograms/ml) and 3MOI (25 micrograms/ml). Results of the present work diminish the possibility that the pneumotoxic effect of 3MI is due to a primary hydrodynamic imbalance across the alveolocapillary membrane resulting in excess filtration over reabsorption.
将来自小牛肺静脉、肺动脉、气管和支气管的平滑肌条在器官浴中与3-甲基吲哚（3MI）和3-甲基氧化吲哚（3MOI）一起孵育。3MI和3MOI（5 - 640微克/毫升）不会引起任何分离出的平滑肌制剂收缩。当将切碎的牛肺制剂与3MI（20微克/毫升）和3MOI（25微克/毫升）一起孵育时，未获得过敏反应介质释放的证据。本研究结果降低了3MI的肺毒性作用是由于肺泡毛细血管膜上原发性流体动力学失衡导致滤过超过重吸收的可能性。
