[Characteristics of interferon production with different administration schedules of inducers].

The results of the study of interferon production after multiple administrations of various interferon inducers in mice are presented. Irrespective of the type of inducer, the state of refractoriness developed 2-3 days after the 1st administration of the inducer due to which repeated administrations of the inducers due to which repeated administrations of the inducers for up to 6 days did not induce significant amounts of interferon; on the contrary, a 30-fold decrease of interferon production was observed. Daily administration of the inducers for 4 and 6 times did not result in the overcoming or prolongation of the state of refractoriness. Different schedules of multiple inducer administrations were tested. Better results were obtained after administration of a double-stranded RNA at 1, 3, 6, and 8 days yielding high levels of interferon production after each administration of the inducer.