Nosik N N, Tazulakhova E B, Saiĭtkulov A M, Ershov F I
Vopr Virusol. 1982 Nov-Dec;27(6):732-5.
The results of the study of interferon production after multiple administrations of various interferon inducers in mice are presented. Irrespective of the type of inducer, the state of refractoriness developed 2-3 days after the 1st administration of the inducer due to which repeated administrations of the inducers due to which repeated administrations of the inducers for up to 6 days did not induce significant amounts of interferon; on the contrary, a 30-fold decrease of interferon production was observed. Daily administration of the inducers for 4 and 6 times did not result in the overcoming or prolongation of the state of refractoriness. Different schedules of multiple inducer administrations were tested. Better results were obtained after administration of a double-stranded RNA at 1, 3, 6, and 8 days yielding high levels of interferon production after each administration of the inducer.
本文呈现了在小鼠中多次给予各种干扰素诱导剂后干扰素产生的研究结果。无论诱导剂的类型如何，在首次给予诱导剂后2 - 3天会出现不应性状态，这导致在长达6天内重复给予诱导剂不会诱导产生大量干扰素；相反，观察到干扰素产生量下降了30倍。每天给予诱导剂4次和6次均未导致不应性状态的克服或延长。测试了多种诱导剂多次给药的不同方案。在第1、3、6和8天给予双链RNA后获得了更好的结果，每次给予诱导剂后均产生高水平的干扰素。
