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针对口蹄疫病毒146S和12S颗粒的单克隆抗体。

Monoclonal antibodies against foot-and-mouth disease virus 146S and 12S particles.

作者信息

McCullough K C, Butcher R

出版信息

Arch Virol. 1982;74(1):1-9. doi: 10.1007/BF01320777.

DOI:10.1007/BF01320777
PMID:6186225
Abstract

This paper is the first description of monoclonal antibodies specific for foot-and-mouth disease virus (FMDV). Using these antibodies, it was possible to distinguish similar and unique antigenic sites on complete (146S) or subunit (12S) virus particles. Some of these monoclonal antibodies could also distinguish between 12S subunits made by acid degradation of 146S virus (12SA) and those viral components found in infected cell lysates which sediment in sucrose density gradients as "12S subunits" (12SN).

摘要

本文首次描述了针对口蹄疫病毒（FMDV）的单克隆抗体。利用这些抗体，能够区分完整（146S）或亚基（12S）病毒颗粒上相似和独特的抗原位点。其中一些单克隆抗体还能区分由146S病毒经酸降解产生的12S亚基（12SA）和感染细胞裂解物中在蔗糖密度梯度中沉降为“12S亚基”（12SN）的病毒成分。

相似文献

1
Monoclonal antibodies against foot-and-mouth disease virus 146S and 12S particles.针对口蹄疫病毒146S和12S颗粒的单克隆抗体。
Arch Virol. 1982;74(1):1-9. doi: 10.1007/BF01320777.
2
Antibody response to 146S particle, 12S protein subunit and isolated VP1 polypeptide of foot-and-mouth disease virus type Asia-1.针对亚洲1型口蹄疫病毒146S颗粒、12S蛋白亚基及分离的VP1多肽的抗体反应。
Vet Microbiol. 1994 Mar;39(1-2):135-43. doi: 10.1016/0378-1135(94)90094-9.
3
Analysis of foot-and-mouth disease virus type O1 Brugge neutralization epitopes using monoclonal antibodies.利用单克隆抗体分析O1布吕赫口蹄疫病毒中和表位
J Gen Virol. 1986 Oct;67 ( Pt 10):2083-92. doi: 10.1099/0022-1317-67-10-2083.
4
Preparation and characterization of monoclonal antibodies to foot-and-mouth disease virus type Asia-1.亚洲1型口蹄疫病毒单克隆抗体的制备与鉴定
Biochemistry (Mosc). 1997 May;62(5):469-73.
5
Serological and immunological relations between the 146S and 12S particles of foot-and-mouth disease virus.口蹄疫病毒146S和12S颗粒之间的血清学和免疫学关系。
J Gen Virol. 1980 Oct;50(2):369-75. doi: 10.1099/0022-1317-50-2-369.
6
Comparative immunogenicity of 146S, 75S and 12S particles of foot-and-mouth disease virus.
Arch Virol. 1982;73(2):185-91. doi: 10.1007/BF01314726.
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The main antigenic determinant detected by neutralizing monoclonal antibodies on the intact foot-and-mouth disease virus particle is absent from isolated VPI.在完整的口蹄疫病毒颗粒上，通过中和单克隆抗体检测到的主要抗原决定簇在分离出的VPI中不存在。
J Gen Virol. 1983 May;64(Pt 5):1193-8. doi: 10.1099/0022-1317-64-5-1193.
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Alteration in antibody reactivity with foot-and-mouth disease virus (FMDV) 146S antigen before and after binding to a solid phase or complexing with specific antibody.与口蹄疫病毒（FMDV）146S抗原结合至固相之前和之后以及与特异性抗体复合之后抗体反应性的改变。
J Immunol Methods. 1985 Sep 3;82(1):91-100. doi: 10.1016/0022-1759(85)90228-5.
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Nature of the antibody response to the foot-and-mouth disease virus particle, its 12S protein subunit and the isolated immunizing polypeptide VP1.
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Quantification of intact 146S foot-and-mouth disease antigen for vaccine production by a double antibody sandwich ELISA using monoclonal antibodies.使用单克隆抗体通过双抗体夹心ELISA对用于疫苗生产的完整146S口蹄疫抗原进行定量分析。
Biologicals. 1990 Oct;18(4):315-9. doi: 10.1016/1045-1056(90)90036-y.

引用本文的文献

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Isolation of Single-Domain Antibody Fragments That Preferentially Detect Intact (146S) Particles of Foot-and-Mouth Disease Virus for Use in Vaccine Quality Control.用于疫苗质量控制的优先检测口蹄疫病毒完整（146S）颗粒的单域抗体片段的分离
Front Immunol. 2017 Aug 17;8:960. doi: 10.3389/fimmu.2017.00960. eCollection 2017.
2
Regulation of porcine plasmacytoid dendritic cells by cytokines.细胞因子对猪浆细胞样树突状细胞的调控。
PLoS One. 2013;8(4):e60893. doi: 10.1371/journal.pone.0060893. Epub 2013 Apr 8.
3
Interplay of foot-and-mouth disease virus, antibodies and plasmacytoid dendritic cells: virus opsonization under non-neutralizing conditions results in enhanced interferon-alpha responses.

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Epitopes on foot-and-mouth disease virus outer capsid protein VP1 involved in neutralization and cell attachment.口蹄疫病毒外衣壳蛋白VP1上参与中和作用及细胞附着的表位。
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Monoclonal antibodies against measles virus.抗麻疹病毒单克隆抗体。
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Cloned viral protein vaccine for foot-and-mouth disease: responses in cattle and swine.口蹄疫克隆病毒蛋白疫苗：牛和猪的反应
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A hybridoma cell line secreting antibody to poliovirus type 3 D-antigen: detection in virus harvest of two D-antigen populations.一种分泌针对脊髓灰质炎病毒3型D抗原抗体的杂交瘤细胞系：在病毒收获物中检测到两种D抗原群体。
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A study of the cross-reacting antigens on the intact foot-and-mouth disease virus and its 12S Subunits with antisera against the structural proteins.一项关于完整口蹄疫病毒及其12S亚基上与抗结构蛋白抗血清发生交叉反应的抗原的研究。
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Neutralization of foot-and-mouth disease virus. I. Sensitization of the 140S virion by antibody also reactive with the 12S protein subunit.口蹄疫病毒的中和作用。I. 抗体对140S病毒粒子的致敏作用，该抗体也与12S蛋白质亚基发生反应。
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