Waldorff S, Buch J
Clin Pharmacol Ther. 1978 Jan;23(1):19-24. doi: 10.1002/cpt197823119.
A prospective study of consecutive patients admitted to a medical service was undertaken to evaluate the prevalence of cardiac digitalis toxicity and the relative diagnostic values of serum digoxin versus an empiric method, based on calculations of digoxin dose in relation to kidney function and body weight. Of 711 patients admitted, 109 were treated with digitalis on admission. Sixteen of the patients developed cardiac arrhythmias consistent with digitalis intoxication. Five of these, none with serum digoxin above 1.6 ng/ml, were not toxic. The remaining eleven patients, all with serum digoxin levels above 1.6 ng/ml, were either definitely or possibly toxic. A similar borderline between intoxicated and nonintoxicated patients could not be established on the basis of calculations based on body weight and renal function. In all cases in which suspicion of digitalis intoxication was raised, serum digoxin measurements could discriminate between the toxic and the nontoxic patients.
对内科病房连续收治的患者进行了一项前瞻性研究，以评估心脏洋地黄毒性的患病率，以及血清地高辛与一种基于肾功能和体重计算地高辛剂量的经验性方法的相对诊断价值。在收治的711例患者中，109例入院时接受了洋地黄治疗。其中16例患者出现了符合洋地黄中毒的心律失常。其中5例患者血清地高辛水平均未超过1.6 ng/ml，并非中毒。其余11例患者血清地高辛水平均超过1.6 ng/ml，确定或可能为中毒。基于体重和肾功能的计算无法在中毒和未中毒患者之间建立类似的界限。在所有怀疑洋地黄中毒的病例中，血清地高辛测量可区分中毒和未中毒患者。
