van Oost B A, Veldhuyzen B F, van Houwelingen H C, Timmermans A P, Sixma J J
Thromb Haemost. 1982 Dec 27;48(3):289-93.
Platelets tests, acute phase reactants and serum lipids were measured in patients with diabetes mellitus and patients with peripheral vascular disease. Patients frequently had abnormal platelet tests and significantly increased acute phase reactants and serum lipids, compared to young healthy control subjects. These differences were compared with multidiscriminant analysis. Patients could be separated in part from the control subjects with variables derived from the measurement of acute phase proteins and serum lipids. Platelet test results improved the separation between diabetics and control subjects, but not between patients with peripheral vascular disease and control subjects. Diabetic patients with severe retinopathy frequently had evidence of platelet activation. They also had increased acute phase reactants and serum lipids compared to diabetics with absent or non-proliferative retinopathy. In patients with peripheral vascular disease, only the fibrinogen concentration was related to the degree of vessel damage by arteriography.
对糖尿病患者和外周血管疾病患者进行了血小板检测、急性期反应物和血脂检测。与年轻健康对照受试者相比，这些患者经常出现血小板检测异常，急性期反应物和血脂显著升高。通过多判别分析对这些差异进行了比较。利用急性期蛋白和血脂测量得出的变量，患者在一定程度上可以与对照受试者区分开来。血小板检测结果改善了糖尿病患者与对照受试者之间的区分，但对外周血管疾病患者与对照受试者之间的区分没有帮助。患有严重视网膜病变的糖尿病患者经常有血小板活化的迹象。与无视网膜病变或非增殖性视网膜病变的糖尿病患者相比，他们的急性期反应物和血脂也有所升高。在外周血管疾病患者中，只有纤维蛋白原浓度与动脉造影显示的血管损伤程度有关。
