Miser A W, Davis D M, Hughes C S, Mulne A F, Miser J S
Am J Dis Child. 1983 Apr;137(4):383-5. doi: 10.1001/archpedi.1983.02140300061017.
Seventeen children with severe pain due to malignant neoplasm were successfully treated with a subcutaneous infusion of morphine sulfate using a syringe pump. Pain relief was adequate in every case without major side effects. The median dosage required was 0.06 mg/kg/hr (range, 0.025 to 1.79 mg/kg/hr). Three patients received the subcutaneous infusion at home. No patient required an intravenous line for pain control.
17名因恶性肿瘤导致剧痛的儿童使用注射泵皮下输注硫酸吗啡后得到成功治疗。所有病例疼痛均得到充分缓解,且无严重副作用。所需的中位剂量为0.06毫克/千克/小时(范围为0.025至1.79毫克/千克/小时)。3名患者在家中接受皮下输注。无一例患者需要静脉置管来控制疼痛。