Galamba J M, Olsen A K, Crawford M E, Sjøgren P
Tvaerfagligt smertecenter, Bispebjerg Hospital.
Ugeskr Laeger. 1995 Jul 17;157(29):4126-30.
This review article describes pharmacokinetics, pharmaco-dynamics, side effects and the practical use of continuous subcutaneous infusion of opioids in cancer patients with pain. Clinical studies have shown that the analgesic effects of continuous subcutaneous infusion of morphine are comparable to continuous intravenous morphine, and that the treatment modality is associated with a low frequency of side-effects and complications. Continuous subcutaneous infusions of morphine are therefore recommended as the treatment of choice for cancer patients with pain, when oral analgesic treatment is no longer possible.
这篇综述文章描述了阿片类药物持续皮下输注在癌痛患者中的药代动力学、药效学、副作用及实际应用。临床研究表明，吗啡持续皮下输注的镇痛效果与吗啡持续静脉输注相当，且该治疗方式副作用和并发症发生率较低。因此，当口服镇痛治疗不再可行时，推荐吗啡持续皮下输注作为癌痛患者的首选治疗方法。
