Sakamoto H, Kawamitsu H, Miwa M, Terada M, Sugimura T
J Antibiot (Tokyo). 1983 Mar;36(3):296-300. doi: 10.7164/antibiotics.36.296.
The cytotoxic effects of bleomycin on HeLa cells in culture were enhanced by incubation of the cells with benzamide, a potent inhibitor of poly(ADP-ribose) polymerase, at concentrations at which benzamide alone did not show any cytotoxicity. Benzamide plus bleomycin display enhanced therapeutic effects against Ehrlich ascites tumor cells in vivo. On daily treatment with various doses of bleomycin plus benzamide for 10 days, mice with Ehrlich ascites tumors survived longer than mice on treatment with bleomycin alone.
在培养的HeLa细胞中，博来霉素的细胞毒性作用通过将细胞与聚（ADP - 核糖）聚合酶的有效抑制剂苯甲酰胺一起孵育而增强，苯甲酰胺单独使用时在该浓度下未显示任何细胞毒性。苯甲酰胺加博来霉素在体内对艾氏腹水肿瘤细胞显示出增强的治疗效果。在用不同剂量的博来霉素加苯甲酰胺每日治疗10天的情况下，患有艾氏腹水肿瘤的小鼠比单独用博来霉素治疗的小鼠存活时间更长。
