在叙利亚金黄地鼠中进行气管内滴注汽车尾气冷凝物。
Intratracheal instillation of automobile exhaust condensate in Syrian golden hamsters.
作者信息
Green U, Warnecke H, Schneider P, Mohr U
出版信息
J Cancer Res Clin Oncol. 1983;105(1):24-6. doi: 10.1007/BF00391827.
Abstract
Male Syrian golden hamsters were intratracheally instilled with automobile exhaust condensate at dose levels of 0.306, 0.613, 1.25, 2.5, and 5.0 mg/hamster once a fortnight for 78 weeks. While a total of six tumors were found in the trachea and lung, hamsters treated with the vehicle only showed no respiratory tract neoplasms. Bronchiogenic adenomatous proliferations and hyperplastic nodules in the lung occurred in all groups, with a significant difference in incidence being seen between the high-dose groups and the controls.
摘要
雄性叙利亚金黄地鼠每隔一周接受一次气管内滴注汽车尾气冷凝物，剂量分别为0.306、0.613、1.25、2.5和5.0毫克/只，持续78周。虽然在气管和肺中总共发现了6个肿瘤，但仅接受赋形剂处理的仓鼠未出现呼吸道肿瘤。所有组均出现了肺内支气管源性腺瘤样增生和增生性结节，高剂量组与对照组之间的发生率存在显著差异。
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