Yamada A, Hayami M
J Natl Cancer Inst. 1983 Apr;70(4):735-8.
Spleen cells taken from quails treated with chicken alpha-fetoprotein (Ch-AFP) showed reduced natural killer (NK) activity as did spleen cells taken from quails treated with chicken amniotic fluid (ChAmF) in which the presence of Ch-AFP was demonstrated by a gel precipitation test. The Ch-AFP-induced reduction of NK activity was shown to be mediated by suppressor cells. In addition, Ch-AFP-treated quails developed tumors with shorter latent periods than those of the tumors that developed in untreated quails after inoculation with Rous sarcoma virus, as was true for ChAmF-treated quails.
取自用鸡甲胎蛋白（Ch-AFP）处理过的鹌鹑的脾细胞，其天然杀伤（NK）活性降低，取自用鸡羊水（ChAmF）处理过的鹌鹑的脾细胞也是如此，凝胶沉淀试验证明ChAmF中存在Ch-AFP。Ch-AFP诱导的NK活性降低被证明是由抑制细胞介导的。此外，与ChAmF处理的鹌鹑一样，Ch-AFP处理的鹌鹑接种劳氏肉瘤病毒后，肿瘤潜伏期比未处理鹌鹑的肿瘤潜伏期短。
