Coovadia H M, Wesley A, Henderson L G, Brain P, Vos G H, Hallett A F
Int Arch Allergy Appl Immunol. 1978;56(1):14-23. doi: 10.1159/000231998.
Immune responses in 24 children with acute measles (AM) were compared with those in 20 children who had chronic pulmonary complications (CPMC) following measles. The immuno-suppressive effects of acute measles were extensive: total white cells were reduced and this reduction was accounted for entirely by lymphopenia which was equally expressed among the major lymphocyte sub-populations studied; the function of 'T' cells, assessed by radio-isotope incorporation into phytohaemagglutin (PHA) transformed lymphocytes and delayed skin hypersensitivity (DHR) to dinitrochlorobenzene (DNCB), was depressed. Serum IgA was reduced in AM patients. In contrast there was a relative sparing of the measured indices of immunity in patients with chronic post-measles chest disease, with the major defect being an impaired DHR to DNCB. There were minor alterations of complement components in both groups of patients.
对24名患急性麻疹（AM）的儿童与20名患麻疹后出现慢性肺部并发症（CPMC）的儿童的免疫反应进行了比较。急性麻疹的免疫抑制作用广泛：白细胞总数减少，这种减少完全是由淋巴细胞减少引起的，在所研究的主要淋巴细胞亚群中均有同等程度的表现；通过放射性同位素掺入植物血凝素（PHA）转化的淋巴细胞以及对二硝基氯苯（DNCB）的迟发性皮肤超敏反应（DHR）评估的“T”细胞功能受到抑制。AM患者的血清IgA降低。相比之下，患麻疹后慢性胸部疾病患者的免疫指标相对未受影响，主要缺陷是对DNCB的DHR受损。两组患者的补体成分均有轻微改变。
