麻疹后的免疫恢复
Immunological recovery after measles.
作者信息
Wesley A, Coovadia H M, Henderson L
出版信息
Clin Exp Immunol. 1978 Jun;32(3):540-4.
Abstract
Twenty-two children with measles were studied at the stage of the rash and 6 weeks later, and results compared with matched controls. The total lymphocyte count and lymphocyte subpopulations with T- and B-cell markers and those with absence of both markers (null cells) were significantly below control levels in the acute phase. At 6 weeks the B-cell and null-cell counts were still significantly diminished. The function of T cells assessed by 14C uptake of phytohaemagglutinin-stimulated lymphocytes and the delayed skin hypersensitivity reaction to dinitrochlorobenzene was impaired during the acute stage, and this persisted for 6 weeks. Over the 6 weeks of study there was a small but significant rise in serum IgG, IgM and complement factors.
摘要
对22名患麻疹儿童在出疹期及6周后进行了研究，并将结果与配对的对照组进行比较。急性期时，总淋巴细胞计数以及带有T细胞和B细胞标志物的淋巴细胞亚群，还有那些既无T细胞也无B细胞标志物的细胞（裸细胞）均显著低于对照水平。6周时，B细胞和裸细胞计数仍显著减少。通过对植物血凝素刺激的淋巴细胞进行¹⁴C摄取评估的T细胞功能以及对二硝基氯苯的迟发性皮肤超敏反应在急性期受损，并持续了6周。在为期6周的研究中，血清IgG、IgM和补体因子有小幅但显著的升高。
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