Jonker M, Malissen B, Mawas C
Transplantation. 1983 Apr;35(4):374-8. doi: 10.1097/00007890-198304000-00022.
Rhesus monkeys were treated in vivo with monoclonal antibodies specific for human cytotoxic T cells. These antibodies reacted with rhesus lymphocytes as they do with human lymphocytes. Injection of a pool of monoclonal antibodies resulted in rapid elimination of the relevant T cell subpopulation from the circulation. Injection of a single monoclonal antibody did not result in elimination of the subpopulation, but the cells were coated with the injected monoclonal antibody. Injection of the single monoclonal antibody did not prolong the allogeneic skin graft. These results indicate that the rhesus monkey is a useful model for testing antihuman monoclonal antibodies.
恒河猴在体内接受了针对人类细胞毒性T细胞的单克隆抗体治疗。这些抗体与恒河猴淋巴细胞的反应和它们与人类淋巴细胞的反应一样。注射一组单克隆抗体导致循环中相关T细胞亚群迅速清除。注射单一单克隆抗体并未导致该亚群的清除，但细胞被注入的单克隆抗体所包被。注射单一单克隆抗体并未延长同种异体皮肤移植的存活时间。这些结果表明，恒河猴是测试抗人单克隆抗体的有用模型。
