Savu L, Zouaghi H, Nunez E A
Biochem Biophys Res Commun. 1983 Feb 10;110(3):796-803. doi: 10.1016/0006-291x(83)91032-x.
The acute phase of an inflammation induced in young rats, at various ages between 1 and 21 days after birth, by a single subcutaneous turpentine injection, is accompanied by a 35%-45% decrease of the alpha 1-foetoprotein serum concentrations. This fall is demonstrated with equilibrium dialysis binding methods, evidencing the loss of about 1/3 of the high affinity estrogen binding sites characteristic for the rat foetoprotein, as well as by specific immunoassay of the foetoprotein concentrations. This negative response is coincidental with classical inflammatory changes of the plasma proteins, similar to those defined in adults: in particular we evidence 5 to 10 fold rises of haptoglobin, as early as the first post-natal day. We discuss the implications of these findings for ontogenic and mechanistic aspects of the inflammatory response.
通过皮下单次注射松节油，在出生后1至21天不同年龄的幼鼠中诱导炎症，其急性期伴随着血清α1-甲胎蛋白浓度降低35%-45%。采用平衡透析结合法证实了这种下降，表明大鼠甲胎蛋白特有的约1/3高亲和力雌激素结合位点丧失，同时也通过甲胎蛋白浓度的特异性免疫测定得到证实。这种阴性反应与血浆蛋白的典型炎症变化同时出现，类似于在成体中所定义的变化：特别是我们发现，早在出生后第一天，触珠蛋白就升高了5至10倍。我们讨论了这些发现对炎症反应的个体发生和机制方面的影响。
