Hesp F L, Hendriks T, Lubbers E J, de Boer H H
Dis Colon Rectum. 1984 Jul;27(7):462-7. doi: 10.1007/BF02555541.
The healing of both rabbit ileal and colonic infected anastomoses has been investigated. Infection was induced by implanting a capsule with human fecal material in the anastomotic area. Infection did result in lowered bursting pressures, which effect was most pronounced in ileum seven days postoperatively. In general, the average hydroxyproline levels in and around infected anastomoses were lower than the hydroxyproline concentrations measured around noninfected anastomoses. This difference was most significant in the segment proximal to the ileal anastomosis seven days after operation, in the segment distal to the colonic anastomosis three days after operation, and in the segment proximal to the colonic anastomosis seven days after operation. It is concluded that infection interferes with the early stages of the healing sequence in rabbit intestinal anastomoses, profoundly affecting collagen metabolism. Our work does not support recent publications that report an unchanged or even increased wound strength under infected conditions.
对兔回肠和结肠感染性吻合口的愈合情况进行了研究。通过在吻合口区植入装有人类粪便的胶囊来引发感染。感染确实导致破裂压力降低，这种影响在术后7天的回肠中最为明显。一般来说，感染性吻合口及其周围的平均羟脯氨酸水平低于未感染吻合口周围测得的羟脯氨酸浓度。这种差异在术后7天回肠吻合口近端的节段、术后3天结肠吻合口远端的节段以及术后7天结肠吻合口近端的节段最为显著。得出的结论是，感染会干扰兔肠吻合口愈合过程的早期阶段，对胶原蛋白代谢产生深远影响。我们的研究不支持最近一些报道，即在感染条件下伤口强度不变甚至增加的观点。
