Reddy P M, Nagaya H, Pascual H C, Lee S K, Gupta S, Lauridsen J I, Jerome D C
J Allergy Clin Immunol. 1978 Jan;61(1):36-41. doi: 10.1016/0091-6749(78)90471-2.
In an attempt to determine the clinical relevance of positive intracutaneous tests when epicutaneous tests are negative, 34 patients with symptoms of perennial rhinitis who had negative epicutaneous but positive intracutaneous tests were evaluated by radioallergosorbent (RAST) test, nasal provocation (NP) tests and leukocyte histamine release (LHR) assay. Nineteen patients with perennial rhinitis who had positive epicutaneous tests and 13 normal healthy volunteers were also studied as positive and negative controls, respectively. None of the 34 patients with negative epicutaneous but positive intracutaneous tests had positive RASTs or LHR assays, but 1 patient had a positive NP test. In contrast, of the 19 patients with positive epicutaneous tests, 12 patients had positive RASTs, 17 had positive LHR assays, and 17 had positive NP tests. In the negative control group of 13 subjects, none had positive RAST, LHR assays, or NP tests, although 3 subjects showed positive intracutaneous tests. These results indicate that when epicutaneous tests are negative in patients with perennial rhinitis, positive intracutaneous tests are not likely to indicate the presence of reaginic allergy.
为了确定皮上试验阴性时皮内试验阳性的临床相关性，对34例常年性鼻炎症状患者进行了评估，这些患者皮上试验阴性但皮内试验阳性，采用放射变应原吸附试验（RAST）、鼻激发试验（NP）和白细胞组胺释放试验（LHR）。19例皮上试验阳性的常年性鼻炎患者和13名正常健康志愿者分别作为阳性和阴性对照进行研究。34例皮上试验阴性但皮内试验阳性的患者中，无一例RAST或LHR试验呈阳性，但有1例患者鼻激发试验呈阳性。相比之下，19例皮上试验阳性的患者中，12例RAST试验呈阳性，17例LHR试验呈阳性，17例鼻激发试验呈阳性。在13名受试者的阴性对照组中，尽管有3名受试者皮内试验呈阳性，但无一例RAST、LHR试验或鼻激发试验呈阳性。这些结果表明，常年性鼻炎患者皮上试验阴性时，皮内试验阳性不太可能提示反应素性过敏的存在。
