Mason P A, Law B, Moffat A C
J Immunoassay. 1983;4(1):83-98. doi: 10.1080/15321818308057001.
Four [125I]iodine labelled amphetamine derivatives were synthesised. Three of these proved useful in the development of radioimmunoassays for amphetamine. The assays, all using the same antiserum, had widely differing specificities for compounds closely related to amphetamine. Thus, chemical modification of the radiotracer was used to tune radioimmunoassay specificity without recourse to the production of different antisera.
合成了四种[125I]碘标记的苯丙胺衍生物。其中三种被证明可用于开发苯丙胺的放射免疫分析。所有这些分析都使用相同的抗血清，但对与苯丙胺密切相关的化合物具有广泛不同的特异性。因此，利用放射性示踪剂的化学修饰来调节放射免疫分析的特异性，而无需制备不同的抗血清。
