Budd R D
Clin Toxicol. 1981 Jan;18(1):91-110. doi: 10.3109/15563658108990015.
Over 60 different amphetamine-related amines were analyzed by EMIT (Enzyme Multiplied Immunoassay Technique) at several different concentrations. An attempt is made to relate structural differences to the affinity of the compounds for the EMIT amphetamine antibody. The effects of substituent placement on the amphetamine molecule are studied. Addition of a single alkyl group to the nitrogen of amphetamine increased reactivity, whereas all other structural changes had the reverse effect, decreasing reactivity.
采用酶增强免疫测定技术（EMIT）对60多种不同的苯丙胺相关胺类进行了几种不同浓度的分析。试图将结构差异与这些化合物对EMIT苯丙胺抗体的亲和力联系起来。研究了取代基在苯丙胺分子上的位置所产生的影响。在苯丙胺的氮原子上添加单个烷基会增加反应活性，而所有其他结构变化则产生相反的效果，即降低反应活性。
