Jeong Yun Cheol, Hwang Young Hoon
Department of Ophthalmology, Konyang University, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Seoul, Korea.
PLoS One. 2016 Aug 4;11(8):e0160662. doi: 10.1371/journal.pone.0160662. eCollection 2016.
To estimate the etiology and features of the eyes with rubeosis iridis among Korean patients.
This study is a retrospective review of 533 Korean patients with rubeosis iridis who visited an eye hospital in Seoul, Korea. We defined rubeosis iridis as visible blood vessels on the iris surface detected during a slit-lamp examination. All cases were reviewed for age at the time of diagnosis, medical history, the most likely cause of rubeosis iridis, visual acuity, and intraocular pressure.
The most commonly observed cause of rubeosis iridis was diabetic retinopathy (DR; n = 337, 63.2%), followed by retinal vein occlusion (RVO; n = 101, 18.9%), ocular ischemic syndrome (OIS; n = 24, 4.5%), retinal detachment (n = 17, 3.2%), and uveitis (n = 15, 2.8%). The cause was classified as miscellaneous in 18 cases (3.4%); in 21 eyes (3.9%), the cause was not clear. Age at the time of rubeosis iridis diagnosis was lower in patients with DR (56.5 years) than in those with RVO (61.0 years) and OIS (64.8 years; P < 0.01). Intraocular pressure of the eyes with DR (37.3 mmHg) and RVO (39.5 mmHg) was higher than that of the eyes with OIS (25.8 mmHg; P < 0.01).
In our population-based single center study, DR was the leading cause of rubeosis iridis followed by RVO and OIS among Korean patients. The clinical characteristics of the eyes with rubeosis iridis differed according to etiology. This finding may be useful when assessing eyes with rubeosis iridis.
评估韩国患者虹膜红变的病因及特征。
本研究对533例就诊于韩国首尔一家眼科医院的韩国虹膜红变患者进行回顾性分析。我们将虹膜红变定义为裂隙灯检查时在虹膜表面可见的血管。所有病例均回顾了诊断时的年龄、病史、虹膜红变最可能的病因、视力和眼压。
虹膜红变最常见的病因是糖尿病视网膜病变（DR；n = 337，63.2%），其次是视网膜静脉阻塞（RVO；n = 101，18.9%）、眼部缺血综合征（OIS；n = 24，4.5%）、视网膜脱离（n = 17，3.2%）和葡萄膜炎（n = 15，2.8%）。18例（3.4%）病因分类为其他；21只眼（3.9%）病因不明。DR患者虹膜红变诊断时的年龄（56.5岁）低于RVO患者（61.0岁）和OIS患者（64.8岁；P < 0.01）。DR组（37.3 mmHg）和RVO组（39.5 mmHg）的眼压高于OIS组（25.8 mmHg；P < 0.01）。
在我们基于人群的单中心研究中，DR是韩国患者虹膜红变的主要病因，其次是RVO和OIS。虹膜红变患者的临床特征因病因不同而有所差异。这一发现可能有助于评估虹膜红变患者。
