Kulics J, Dekegel M, Naessens J, Van der Loo W, Hamers R
Mol Immunol. 1983 Jan;20(1):101-11. doi: 10.1016/0161-5890(83)90109-8.
A number of allotypic markers of the rabbit immunoglobulins are present only on intact immunoglobulin molecules and not on the isolated heavy or light chains. Some of these markers, although determined by the kappa light chain, are limited to a single heavy chain class of Ig. They can be generated by in vitro hybridization of the kappa light chain with the appropriate heavy chain. The quaternary IgG allotypic determinants Gs3 and Gs7 which are determined respectively by the b4.1 and b4.2 allelic variants of the kappa b4 light chain can be generated not only by in vitro hybridization of these light chains with a rabbit gamma chain, but also to a certain extent by their hybridization to gamma chains derived from other species.
兔免疫球蛋白的许多同种异型标记仅存在于完整的免疫球蛋白分子上，而不存在于分离的重链或轻链上。其中一些标记虽然由κ轻链决定，但仅限于Ig的单一重链类别。它们可通过κ轻链与适当重链的体外杂交产生。κb4轻链的b4.1和b4.2等位基因变体分别决定的四级IgG同种异型决定簇Gs3和Gs7，不仅可通过这些轻链与兔γ链的体外杂交产生，在一定程度上还可通过它们与源自其他物种的γ链杂交产生。
