孕妇血清存在时淋巴细胞对植物血凝素的反应：与甲胎蛋白血清水平的相关性
Lymphocyte response to phytohaemagglutinin in the presence of serum from pregnant women: correlation with serum levels of alpha-foetoprotein.
作者信息
Figueredo M A, Palomino P, Ortiz F
出版信息
Clin Exp Immunol. 1979 Jul;37(1):140-4.
The effect of sera from women in different stages of pregnancy on cultures of human lymphocytes stimulated with phytohaemagglutinin (PHA) has been studied and correlated with alpha-foetoprotein (AFP) levels. Sera taken before the twentieth week of gestation showed low levels of AFP and failed to inhibit lymphocyte proliferation. Inhibition was obtained with 38.5% of sera taken from weeks 20 to 30 and with 51.7% of sera after the thirtieth week of pregnancy. Average serum levels of AFP also increased with advanced gestation, but a consistent correlation was not found between AFP concentration and inhibitory activity for every individual serum tested. Lymphocytes from pregnant women or from normal blood donors behaved in the same way in these tests. The mechanisms of inhibition and the role of AFP are discussed.
研究了处于不同孕期的女性血清对用植物血凝素（PHA）刺激的人淋巴细胞培养物的影响，并将其与甲胎蛋白（AFP）水平相关联。妊娠20周前采集的血清显示AFP水平较低，且未能抑制淋巴细胞增殖。从妊娠20至30周采集的血清中有38.5%可产生抑制作用，妊娠30周后采集的血清中有51.7%可产生抑制作用。AFP的平均血清水平也随着孕期进展而升高，但在每个测试的个体血清中，未发现AFP浓度与抑制活性之间存在一致的相关性。在这些测试中，来自孕妇或正常献血者的淋巴细胞表现相同。讨论了抑制机制及AFP的作用。
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