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人在睡眠-清醒周期中脑脊液中5-羟吲哚乙酸浓度的变化。

Variations in the 5-hydroxy-indoleacetic acid concentration in the cerebrospinal fluid during the sleep-wake cycle in man.

作者信息

Raffaele R, Reggio A, Tropea R, Pennisi G, Falsaperla A, Nicoletti F

出版信息

Ital J Neurol Sci. 1983 Apr;4(1):35-7. doi: 10.1007/BF02043435.

DOI:10.1007/BF02043435
PMID:6190774
Abstract

A variation in the ventricular fluid 5-HIAA concentration has been observed during the phases of the sleep-wake cycle in man. This variation affects the NREM phase, during which 5-HIAA increases markedly, rather than the waking state and the REM phase. The results are discussed in relation to the possible relevance of serotonin to the sleep mechanism.

摘要

在人类睡眠-觉醒周期各阶段，已观察到脑室液中5-羟吲哚乙酸（5-HIAA）浓度存在变化。这种变化影响非快速眼动（NREM）阶段，在此阶段5-HIAA显著增加，而不影响清醒状态和快速眼动（REM）阶段。结合血清素与睡眠机制的可能相关性对结果进行了讨论。

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本文引用的文献

1
Proposed supplements and amendments to 'A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects', the Rechtschaffen & Kales (1968) standard.对《人类受试者睡眠阶段标准化术语、技术和评分系统手册》（ Rechtschaffen和Kales，1968年标准）的拟议补充和修订。
Psychiatry Clin Neurosci. 2001 Jun;55(3):305-10. doi: 10.1046/j.1440-1819.2001.00810.x.
2
(+)-6-fluorotryptophan, an inhibitor of tryptophan hydroxylase: sleep and wakefulness in the rat.（+）-6-氟色氨酸，一种色氨酸羟化酶抑制剂：对大鼠睡眠和清醒的影响
Neuropharmacology. 1981 Apr;20(4):335-9. doi: 10.1016/0028-3908(81)90005-8.
3
Long-term effects of a tryptophan-free diet on serotonin metabolism and sleep-waking balance in rats.
无色氨酸饮食对大鼠血清素代谢及睡眠-觉醒平衡的长期影响。
Exp Brain Res. 1981;41(3-4):346-57. doi: 10.1007/BF00238892.
4
Circadian variation in 5-hydroxyindoleacetic acid levels in human cerebrospinal fluid.
Eur Neurol. 1981;20(1):9-12. doi: 10.1159/000115197.
5
Effect of tryptophan administration on 5HIAA in cerebrospinal fluid in man.色氨酸给药对人体脑脊液中5-羟吲哚乙酸的影响。
J Neurol Neurosurg Psychiatry. 1970 Apr;33(2):269-72. doi: 10.1136/jnnp.33.2.269.
6
5-hydroxyindoleacetic acid in the brain and cerebrospinal fluid of the rabbit following administration of drugs affecting 5-hydroxytryptamine.给予影响5-羟色胺的药物后家兔脑和脑脊液中的5-羟吲哚乙酸
J Neurochem. 1970 Jun;17(6):827-8. doi: 10.1111/j.1471-4159.1970.tb03357.x.
7
A method for the simultaneous determination of 5-hydroxy-3-indole-acetic acid (5-HIAA) and 5-hydroxytryptamine (5-HT) in brain tissue and cerebrospinal fluid.一种同时测定脑组织和脑脊液中5-羟色胺（5-HIAA）和5-羟色胺（5-HT）的方法。
Acta Physiol Scand. 1970 Jan;78(1):43-51. doi: 10.1111/j.1748-1716.1970.tb04637.x.
8
Cerebral metabolites in cerebrospinal fluid as a biochemical approach to the brain.脑脊液中的脑代谢物作为研究大脑的生化方法。
Brain. 1970;93(2):357-68. doi: 10.1093/brain/93.2.357.
9
The role of monoamines and acetylcholine-containing neurons in the regulation of the sleep-waking cycle.单胺能和胆碱能神经元在睡眠-觉醒周期调节中的作用。
Ergeb Physiol. 1972;64:166-307. doi: 10.1007/3-540-05462-6_2.
10
The serotonin-catecholamine-dream bicycle: a clinical study.
Biol Psychiatry. 1972 Aug;5(1):33-64.