Lidwell O M, Lowbury E J, Whyte W, Blowers R, Stanley S J, Lowe D
J Hosp Infect. 1983 Mar;4(1):19-29. doi: 10.1016/0195-6701(83)90061-0.
A wide variety of bacterial species, many usually regarded as of low pathogenicity, were isolated from septic joints after operation for total hip or knee joint replacement in a multi-centre trial of ultraclean air in operating rooms. The prophylactic antibiotics generally used appeared to reduce considerably the rates of infection with most species but to be ineffective against 'gut' organisms. For about half the septic infections involving Staphylococcus aureus nasal swabs had been obtained from the patient and operating staff at the time of operation for insertion of the prosthesis. Strains of Staph, aureus isolated from these and from the infected joints were phage typed and tested for antibiotic sensitivity. A probable source among the carriers was found for seven out of the 14 infections and a possible source for another five. Very small numbers of Staph. aureus were needed to initiate infection.
在一项关于手术室超净空气的多中心试验中，从全髋关节或膝关节置换手术后的感染关节中分离出了各种各样的细菌物种，其中许多通常被认为致病性较低。一般使用的预防性抗生素似乎能大幅降低大多数物种的感染率，但对“肠道”微生物无效。在大约一半涉及金黄色葡萄球菌的感染性关节炎病例中，在植入假体手术时已从患者和手术人员处获取了鼻拭子。对从这些鼻拭子以及感染关节中分离出的金黄色葡萄球菌菌株进行了噬菌体分型和抗生素敏感性测试。在14例感染病例中，发现了7例的携带者中可能的感染源，另外5例可能的感染源。引发感染只需极少量的金黄色葡萄球菌。
