抗人3型副粘病毒和抗SV5病毒的单克隆抗体：制备与初步特性鉴定

Monoclonal antibodies against human paramyxovirus type 3 and against SV5 virus: preparation and preliminary characterization.

作者信息

Goswami K K, Russell W C

出版信息

J Gen Virol. 1983 Aug;64 (Pt 8):1663-72. doi: 10.1099/0022-1317-64-8-1663.

DOI:10.1099/0022-1317-64-8-1663

Abstract

Monoclonal antibodies against the major glycoprotein (HN) and the nucleoprotein (NP) of paramyxovirus SV5 and human paramyxovirus (PF) type 3 have been obtained. Two different epitopes have been detected on the SV5 HN polypeptide, one being specific to SV5 and the other also cross-reacting with PF-2 HN polypeptide. Monoclonal antibody against SV5 NP polypeptide also reacted with PF-2 NP polypeptide. Similar epitopes showing both specific and group cross-reactions were detected with PF-3 HN and NP monoclonal antibodies against PF-3 and Sendai viruses. No cross-reactions were detected between these two groups of paramyxoviruses.

摘要

已获得针对副粘病毒SV5和人副粘病毒3型（PF）主要糖蛋白（HN）和核蛋白（NP）的单克隆抗体。在SV5 HN多肽上检测到两个不同的表位，一个对SV5具有特异性，另一个也与PF-2 HN多肽发生交叉反应。针对SV5 NP多肽的单克隆抗体也与PF-2 NP多肽发生反应。用针对PF-3和仙台病毒的PF-3 HN和NP单克隆抗体检测到具有特异性和组间交叉反应的相似表位。在这两组副粘病毒之间未检测到交叉反应。

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