一种副粘病毒——猴病毒41（SV41）的抗原性和结构特性显示出与人类2型副流感病毒的密切关系。
Antigenic and structural properties of a paramyxovirus simian virus 41 (SV41) reveal a close relationship with human parainfluenza type 2 virus.
作者信息
Tsurudome M, Bando H, Nishio M, Iwamoto Y, Kawano M, Kondo K, Komada H, Ito Y
机构信息
Department of Microbiology, Mie University School of Medicine, Japan.
出版信息
Virology. 1990 Dec;179(2):738-48. doi: 10.1016/0042-6822(90)90141-d.
Seven structural component proteins of a paramyxovirus simian virus 41 (SV41) were identified with the aid of monoclonal antibodies prepared against SV41 and human parainfluenza type 2 virus (PIV2). The nucleoprotein is antigenically very close to that of PIV2, while it is comparatively far from that of simian virus 5 (SV5). The hemagglutinin-neuraminidase (HN) protein showed no immunological relationship to either of the HN proteins of PIV2 or SV5. The amino acid sequence of the SV41 HN protein was deduced from the nucleotide sequence of its HN gene and revealed that the SV41 HN is unexpectedly close to the PIV2 HN (61.2% identity in amino acid sequence), while the SV5 HN showed only 48.3% identity with the PIV2 HN. The SV41 HN is also related to the SV5 HN (51.3% identity); thus, the SV41 HN is phylogenetically situated between the PIV2 and SV5 HNs. These results indicate that SV41 is the virus closest to PIV2 at present.
借助针对猴病毒41型（SV41）和人副流感病毒2型（PIV2）制备的单克隆抗体，鉴定出了一种副粘病毒——猴病毒41型的七种结构组成蛋白。核蛋白在抗原性上与PIV2的核蛋白非常接近，而与猴病毒5型（SV5）的核蛋白相对较远。血凝素神经氨酸酶（HN）蛋白与PIV2或SV5的任何一种HN蛋白均无免疫关系。从SV41 HN基因的核苷酸序列推导得出SV41 HN蛋白的氨基酸序列，结果显示SV41 HN出人意料地与PIV2 HN接近（氨基酸序列同一性为61.2%），而SV5 HN与PIV2 HN的同一性仅为48.3%。SV41 HN也与SV5 HN相关（同一性为51.3%）；因此，在系统发育上，SV41 HN位于PIV2和SV5 HN之间。这些结果表明，SV41是目前与PIV2最接近的病毒。
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