Phan S H, Thrall R S, Ward P A
Am Rev Respir Dis. 1980 Mar;121(3):501-6. doi: 10.1164/arrd.1980.121.3.501.
The net rate of collagen synthesis in short-term lung explant cultures from rats was examined during a period of 4 wk after administration of a single intratracheal dose of bleomycin. After a delay of 3 to 4 days, the net rate of collagen synthesis was significantly increased over that in untreated control animals. This increase was sustained during approximately 10 days and subsequently returned to normal or below normal values. The increased rate of collagen synthesis could not be explained by increased free radioactive proline pools or by age differences among the animals. The period of increased rate of collagen synthesis preceded the detectable increases in lung collagen content, as we have reported previously.
在给大鼠气管内单次注射博来霉素后的4周内，检测了短期肺外植体培养物中胶原蛋白的合成净速率。延迟3至4天后，胶原蛋白的合成净速率比未处理的对照动物显著增加。这种增加持续了大约10天，随后恢复到正常或低于正常水平。胶原蛋白合成速率的增加不能用游离放射性脯氨酸池的增加或动物之间的年龄差异来解释。正如我们之前所报道的，胶原蛋白合成速率增加的时期先于肺胶原蛋白含量可检测到的增加。
