Hayreh S S, Rojas P, Podhajsky P, Montague P, Woolson R F
Ophthalmology. 1983 May;90(5):488-506. doi: 10.1016/s0161-6420(83)34542-5.
A prospective natural history study was conducted in 721 eyes with various types of retinal vein occlusion (RVO) to determine the incidence of various types of ocular neovascularization (NV) and the factors that influence the development of ocular NV. The material was 360 eyes with central retinal vein occlusion (CRVO), 97 eyes with hemi-CRVO, and 264 eyes with branch retinal vein occlusion (BRVO); these cases were further subdivided into six groups for logical data analysis: nonischemic CRVO (venous stasis retinopathy-VSR, 282 eyes), ischemic CRVO (hemorrhagic retinopathy-HR, 78 eyes), hemi-VSR (66 eyes), hemi-HR (31 eyes), major BRVO (191 eyes) and macular BRVO (73 eyes). Ocular NV attributable to RVO was seen only in HR, hemi-HR, and major BRVO. In HR the anterior segment was the major site of NV, with iris and angle NV and neovascular glaucoma (NVG), while in hemi-HR and major BRVO the retina and optic disc were the major sites of NV. The principal factor influencing the development of ocular NV in RVO seems to be the severity and extent of retinal ischemia, while duration of follow-up since onset also plays an important role in determining the incidence of ocular NV. The findings and subject of ocular NV in RVO are discussed in detail along with a review of the pertinent literature.
对721只患有各种类型视网膜静脉阻塞（RVO）的眼睛进行了一项前瞻性自然史研究，以确定各种类型眼新生血管形成（NV）的发生率以及影响眼NV发展的因素。研究材料包括360只患有视网膜中央静脉阻塞（CRVO）的眼睛、97只患有半侧CRVO的眼睛和264只患有视网膜分支静脉阻塞（BRVO）的眼睛；这些病例进一步细分为六组以进行逻辑数据分析：非缺血性CRVO（静脉淤滞性视网膜病变-VSR，282只眼）、缺血性CRVO（出血性视网膜病变-HR，78只眼）、半侧VSR（66只眼）、半侧HR（31只眼）、主要BRVO（191只眼）和黄斑BRVO（73只眼）。由RVO引起的眼NV仅在HR、半侧HR和主要BRVO中出现。在HR中，前段是NV的主要部位，有虹膜和房角NV以及新生血管性青光眼（NVG），而在半侧HR和主要BRVO中，视网膜和视盘是NV的主要部位。影响RVO中眼NV发展的主要因素似乎是视网膜缺血的严重程度和范围，而发病后的随访时间在确定眼NV的发生率方面也起着重要作用。本文详细讨论了RVO中眼NV的研究结果和主题，并对相关文献进行了综述。
